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Keywords: PTP1B
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Journal Articles
In collection:
Membrane trafficking
J Cell Sci (2023) 136 (6): jcs260566.
Published: 2 March 2023
... into the intraluminal vesicles (ILVs) of multivesicular bodies. Active, phosphorylated EGFR inactivates the LRRK1 kinase activity by phosphorylating Y944. In this study, we demonstrate that LRRK1 facilitates EGFR dephosphorylation by PTP1B (also known as PTPN1), an endoplasmic reticulum (ER)-localized protein tyrosine...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2021) 134 (20): jcs258769.
Published: 21 October 2021
...Ana E. González Wusener; Ángela González; María E. Perez Collado; Melina R. Maza; Ignacio J. General; Carlos O. Arregui ABSTRACT Protein tyrosine phosphatase 1B (PTP1B, also known as PTPN1) is an established regulator of cell-matrix adhesion and motility. However, the nature of substrate targets...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (8): 1820–1831.
Published: 15 April 2013
...Juan E. Burdisso; Ángela González; Carlos O. Arregui Summary Previous findings established that ER-bound PTP1B targets peripheral cell–matrix adhesions and positively regulates cell adhesion to fibronectin. Here we show that PTP1B enhances focal complex lifetime at the lamellipodium base, delaying...
Includes: Supplementary data
Journal Articles
J Cell Sci (2003) 116 (15): 3145–3155.
Published: 1 August 2003
... cell migration. Overexpression of CrkII inhibited dephosphorylation of focal adhesion components such as p130 Crk-associated substrate (p130 cas ) and paxillin by protein tyrosine phosphatase 1B (PTP1B). Tyrosine-phosphorylated CrkII was dephosphorylated by PTP1B both in vitro and in vivo, showing...