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Keywords: PPI
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Journal Articles

Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration

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Catherine Qiurong Pan, Yih-cherng Liou, Boon Chuan Low
Journal: Journal of Cell Science
J Cell Sci (2010) 123 (6): 903–916.
https://doi.org/10.1242/jcs.064162
Published: 15 March 2010
... domain of BPGAP1 interacts with the peptidyl-prolyl cis/trans isomerase (PPI) Pin1, leading to enhanced GAP activity towards RhoA. BPGAP1 also interacted with wild-type and constitutively active Mek2, but not with its kinase-dead mutant. However, only active Mek2 could bind Pin1, acting as a scaffold...
View articletitled, Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration
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Includes: Supplementary data