... proliferator-activated receptor gamma (PPARγ, also known as PPARG) in mice leads to osteopetrosis and pulmonary arterial hypertension. Vascular disease is associated with loss of PPARγ in pulmonary microvascular endothelial cells (PMVEC); we evaluated the role of PPARγ in PMVEC functions, such as angiogenesis...

... complex, negatively regulates adipogenesis through a direct interaction with the DNA-binding domain of peroxisome proliferator-activated receptor γ (PPARγ). We found that AIMP1 expression increases during adipocyte differentiation. Adipogenesis is augmented in AIMP1-deficient cells, as compared...

...Qini Gan; Jing Huang; Rui Zhou; Jing Niu; Xiaojun Zhu; Jing Wang; Zongyu Zhang; Tanjun Tong Peroxisome proliferator-activated receptor γ (PPARγ) plays an important role in the inhibition of cell growth by promoting cell-cycle arrest, and PPARγ activation induces the expression of p16 INK4α (CDKN2A...

... hours (induction period), followed by incubation with insulin for 9 additional days (maturation period). A transient burst of CCAAT/enhancer-binding protein (C/EBP) β and C/EBPδ at an early stage (∼3 hours) and a delayed induction (∼45 hours) of C/EBPα and PPARγ 2 were sequentially provoked during...

... was under hormonal regulation of pituitary gonadotropins and showed stage-specificity, with peak expression values at stages II-VI of the seminiferous epithelial cycle. In addition, testicular resistin mRNA was down-regulated by the selective agonist of PPARγ, rosiglitazone, in vivo and in vitro. Similarly...

... with a growing recognition that the γ isoform (PPARγ) affects pathways important in a variety of human diseases. Here we show that the activation of PPARγ through the 15-deoxy-Δ-12,14-prostaglandin J 2 (PG-J 2 ) ligand causes a dramatic inhibition of ErbB-2 and ErbB-3 tyrosine phosphorylation caused...

...-proliferator-activated-receptor γ (PPARγ), is expressed in CHO/K1 cells. Concomitantly with the formation of lipid droplets, the expression of PPARγ mRNA is increased in CHO/K1-β3 cells, but not in non-transfected CHO/K1 cells. We furthermore detected constitutive expression of another adipocyte-associated...