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Keywords: PML
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Journal Articles
J Cell Sci (2023) 136 (19): jcs261092.
Published: 11 October 2023
... mechanisms responsible for the remodeling of constitutive heterochromatin are largely unknown. Here, we identify that DAXX, an H3.3 chaperone essential for the maintenance of mouse ESCs in the ground state, accumulates in pericentromeric regions independently of DNA methylation. DAXX recruits PML and SETDB1...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2019) 132 (5): jcs222349.
Published: 14 March 2019
... and have a poor prognosis. They are also commonly deficient for expression of ATRX protein, a repressor of ALT activity, and a component of promyelocytic leukemia nuclear bodies (PML NBs) that are required for intrinsic immunity to various viruses. Here, we asked whether ATRX deficiency creates...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (20): 3496–3506.
Published: 15 October 2017
...Chuang Li; Qiongfang Peng; Xiao Wan; Haili Sun; Jun Tang ABSTRACT Promyelocytic leukemia protein (PML) nuclear bodies (NBs), which are sub-nuclear protein structures, are involved in a variety of important cellular functions. PML-NBs are assembled by PML isoforms, and contact between small...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2011) 124 (2): 280–291.
Published: 15 January 2011
... bodies (PML-NBs, also known as ND10) contribute to host restriction of herpes simplex virus type 1 (HSV-1) replication via mechanisms that are counteracted by viral regulatory protein ICP0. ND10 assembly is dependent on PML, which comprises several different isoforms, and depletion of all PML isoforms...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (15): 2613–2622.
Published: 1 August 2009
... to promyelocytic leukemia (PML) nuclear bodies through its interaction with PML-IV. Treatment of interferon-α (IFNα) in H1299 cells resulted in the increase of PML proteins with a concurrent decrease of telomerase activity, as previously reported. PML depletion, however, stimulated telomerase activity that had...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (8): 1201–1210.
Published: 15 April 2009
...Åsne Jul-Larsen; Amra Grudic; Rolf Bjerkvig; Stig Ove Bøe Nucleoporins and the promyelocytic leukemia protein (PML) represent structural entities of nuclear pore complexes and PML nuclear bodies, respectively. In addition, these proteins might function in a common biological mechanism, because...
Includes: Multimedia, Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2006) 119 (16): 3284–3295.
Published: 15 August 2006
...Stig Ove Bøe; Marte Haave; Åsne Jul-Larsen; Amra Grudic; Rolf Bjerkvig; Per Eystein Lønning The promyelocytic leukemia protein (PML) participates in several cellular functions, including transcriptional regulation, apoptosis and maintenance of genomic stability. A key feature of this protein...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2004) 117 (2): 339–349.
Published: 15 January 2004
... binding protein (CBP) and acetylated histone H4, which are markers for transcriptionally active chromatin. Moreover, STAT3 nuclear bodies in HepG2 cells are not colocalized with promyelocytic leukemia oncoprotein (PML)-containing bodies; neither is a sumoylation of activated STAT3 detectable. Taken...
Includes: Multimedia, Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2003) 116 (14): 2957–2966.
Published: 15 July 2003
... with promyelocytic leukemia (PML) protein in nuclear bodies implicated in transcription control. Since Drosophila ten-m acts epistatically to another pair-rule gene opa , we investigated whether gene regulation by the mammalian opa homologue zic-1 was influenced by the intracellular domain of teneurin-2. We found...
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2001) 114 (1): 59–68.
Published: 1 January 2001
...Dmitri Negorev; Alexander M. Ishov; Gerd G. Maul ABSTRACT Nuclear domains called ND10 or PML nuclear bodies consist of an aggregation of several proteins, most notably PML and Sp100. PML is essential in the nucleation and formation of ND10 as well as in the recruitment of other ND10-associated...
Journal Articles
J Cell Sci (1999) 112 (24): 4581–4588.
Published: 15 December 1999
...Roger D. Everett; Patrick Lomonte; Thomas Sternsdorf; Roel van Driel; Anne Orr ABSTRACT The nuclear sub-structures known as ND10, PODs or PML nuclear bodies can be rapidly modified by diverse stimuli, and the resultant structural changes correlate with events such as cellular transformation...
Journal Articles