.... and Raghu , P. (2022). Septins tune lipid kinase activity and PI(4,5)P2 turnover during G-protein–coupled PLC signalling in vivo . Life Sci. Alliance 5 , e202101293 . 10.26508/lsa.202101293 Legate , K. R. , Montag , D. , Böttcher , R. T. , Takahashi , S. and Fässler...

...Sruthi S. Balakrishnan; Urbashi Basu; Dhananjay Shinde; Rajan Thakur; Manish Jaiswal; Padinjat Raghu ABSTRACT The activation of phospholipase C (PLC) is a conserved mechanism of receptor-activated cell signaling at the plasma membrane. PLC hydrolyzes the minor membrane lipid phosphatidylinositol...

...Barbara Peracino; Alessandra Balest; Salvatore Bozzaro Membrane phosphatidylinositides recruit cytosolic proteins to regulate phagocytosis, macropinocytosis and endolysosomal vesicle maturation. Here, we describe effects of inactivation of PI3K, PTEN or PLC on Escherichia coli and Legionella...

... of R-Ras on the actin cytoskeleton and membrane protrusion, because R-Ras was co-precipitated with PLCϵ and increased its activity. Knockdown of PLCϵ with siRNA reduced the formation of the ruffling lamellipod in R-Ras cells. Consistent with this pathway, inhibitors of PLC activity, or chelating...

... activation of phosphoinositide 3-kinase (PI 3-kinase), phospholipase C (PLC) and phospholipase D (PLD). We therefore reexamined whether motility is constitutively triggered by v-Src and studied whether this response is controlled by the same signalling pathway. The study was performed using Rat-1/tsLA29...

... cells (Stewart et al., 1990) as well as intracellular binding sites in the rat cerebral cortex (Marcheselli et al., 1990); however, the mechanism of action is still unknown. Using a non-competitive inhibitor of receptor-mediated IP3 and DAG formation, U73122, which is thought to interfere with PLC...