... and control the lysosomal localization of Rab29 in concert with LRRK2. These results implicate PKCs in the lysosomal stress response pathway comprised of Rab29 and LRRK2, and further underscore the importance of this pathway in the mechanisms underlying lysosomal homeostasis. * These authors...

... governing pinocytosis and exocytosis. PKC Polyphosphate Stationary phase entry Postlysosome Shear stress Although many organisms can pause their cell cycle, entering either a stationary or a quiescent phase, very little is known about the mechanisms controlling stationary phase (SP) entry...

...Yuki Kanda; Ryosuke Satoh; Teruaki Takasaki; Naofumi Tomimoto; Kiko Tsuchiya; Chun An Tsai; Taemi Tanaka; Shu Kyomoto; Kozo Hamada; Toshinobu Fujiwara; Reiko Sugiura ABSTRACT Protein kinase C (PKC) signaling is a highly conserved signaling module that plays a central role in a myriad...

... and equivalent sites). Conventional PKC (cPKC), a critical mediator of the angiotensin type I receptor (AT 1 R, also known as AGTR1) signaling, regulates the subcellular localization of SIN1 (also known as MAPKAP1) and SGK1. Inhibition of cPKC catalytic activity disturbs SIN1 and SGK1 subcellular localization...

... cancer tissues. CD151-dependent regulation of the FGFR2 expression relies on post-transcriptional mechanisms involving HuR (also known as ELAVL1), a multifunctional RNA-binding protein, and the assembly of processing bodies (P-bodies). Depletion of CD151 correlated with inhibition of PKC, a well...

... on PKCδ- and ASMase-mediated modulation of lipid raft size and FasR-mediated apoptosis. Keratin PKC ASMase Lipid raft FasR Hepatocyte Canadian Institutes of Health Research 10.13039/501100000024 MOP 15529 National Institutes of Health DK52951 Keratins...

... adaptor, was shown to attenuate Pmk1 MAPK signaling by regulating the subcellular distribution of the Mkh1 MAPKKK. Schizosaccharomyces pombe PKC MAPKK kinase Skb5 SH3 adaptor protein The mitogen-activated protein kinase (MAPK) signaling cascade is a highly conserved signaling module...

... distinct nanoclusters that do not overlap. Finally, induction of oncogenic K-Ras phosphorylation – by activation of protein kinase C (PKC) – increased its co-clustering with the phosphomimetic K-Ras mutant, whereas (when PKC is inhibited) non-phosphorylated oncogenic K-Ras clusters with the non...

... cancer JNK p38 MAPK PKC The activating transcription factor (ATF; also known as cAMP-dependent transcription factor) and cAMP-response-element-binding (CREB) families of transcription factors comprise 16 members of the activator protein 1 (AP1) transcription factor superfamily. ATF and CREB...

... that SH2B1β is phosphorylated in response to phorbol 12-myristate 13-acetate (PMA)-induced protein kinase C (PKC) activation and show that PMA induces a rapid redistribution of SH2B1β out of focal adhesions. We also show that growth hormone (GH) increases cycling of SH2B1β into and out of focal adhesions...

... is an environmental sensor and its partner BMAL1 is a Class II member ( Gu et al., 2000 ; Hogenesch et al., 1998 ). This phylogenetic interpretation is consistent with previous findings suggesting that CLOCK acts as a bona fide signaling molecule responding to the resetting stimuli via the Ca 2+ -dependent PKC...

[email protected] ) 28 1 2010 © 2010. 2010 Chemokines Astrocytes Schwann cells Cell proliferation Erk p38 PKC Akt The CXC chemokine SDF-1 (stromal cell derived factor-1; also known as CXCL12) was originally isolated as a pre-B-cell growth-stimulating factor...

..., IL, USA 24 4 2008 © The Company of Biologists Limited 2008 2008 AFAP1 AFAP-110 Podosomes PKC Invadopodia Actin filaments Podosomes are dynamic actin-rich adhesion structures that have been identified in highly motile and invasive cells, such as macrophages...

... formation. Both Pak2 and Pak4 phosphorylation strongly correlate with the lumen formation process in a manner that depends on protein kinase C (PKC)-mediated signaling. We identify PKCϵ and PKCζ as regulators of EC lumenogenesis in 3D collagen matrices. Two polarity proteins, Par3 and Par6, are also...

... arrest, and programmed cell death. We now show that Cl – intracellular channel 4 (CLIC4) expression is increased in both mouse and human keratinocytes undergoing differentiation induced by Ca 2+ , serum and the protein kinase C (PKC)-activator, 12- O -tetradecanoyl-phorbol-13-acetate (TPA). Elevation...

...Florence Tatin; Christine Varon; Elisabeth Génot; Violaine Moreau The involvement of Src, Cdc42, RhoA and PKC in the regulation of podosome assembly has been identified in various cell models. In endothelial cells, the ectopic expression of constitutively active mutants of Src or Cdc42...

.... In the phosphate-groove-knockin ES cells, the activation of S6K, RSK and SGK by agonists, although markedly impaired, was not abolished. PDK1 also phosphorylates the T-loop of protein kinase C (PKC) isoforms, which stabilizes these enzymes. However, in contrast to S6K, RSK and SGK, hydrophobic motif...

... at counteracting this condition have not presented complete effectiveness in protecting the integrity of cochlear neural elements. In this context, the protein kinase C (PKC) family of enzymes are important signalling molecules that play a role in preventing neurodegeneration after nervous system injury...

... to total CaM (∼40 μM). Confocal images indicate that calmodulin and MARCKS co-distribute in unstimulated freshly dissociated smooth-muscle cells and are co-targeted simultaneously to the cell interior upon depolarization. Protein-kinase-C (PKC) activation triggers a translocation of CaM that precedes...

...Samudra S. Gangopadhyay; Norio Takizawa; Cynthia Gallant; Amy L. Barber; Hyun-Dong Je; Tara C. Smith; Elizabeth J. Luna; Kathleen G. Morgan The mechanisms by which protein kinase C (PKC) and extracellular-signal-regulated kinases (ERK1/2) govern smooth-muscle contractility remain unclear. Calponin...