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Keywords: PI3-kinase
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Lipid Biology
J Cell Sci (2014) 127 (14): 3104–3115.
Published: 15 July 2014
... stimulates lipid droplet formation by activating the long-chain fatty acid receptor FFAR4, which signals through a pertussis-toxin-sensitive G-protein signalling pathway involving phosphoinositide 3-kinase (PI3-kinase), AKT (also known as protein kinase B) and phospholipase D (PLD) activities. This initial...
Journal Articles
J Cell Sci (2012) 125 (2): 340–349.
Published: 15 January 2012
... and PI3K signaling in a manner mechanistically similar to directed cell locomotion. Erythroblast enucleation PI3-kinase Microtubules Cell polarization In the last step of erythropoiesis, mammalian erythroblasts undergo enucleation, a process that is crucial for the formation of mature...
Includes: Multimedia, Supplementary data
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Journal Articles
J Cell Sci (2003) 116 (7): 1187–1197.
Published: 1 April 2003
... (e-mail: fhollande@ww3.pharma.univ-montp1.fr ) 12 12 2002 © The Company of Biologists Limited 2003 2003 Tight junctions β-catenin Progastrin Src PI3-kinase In polarised epithelia, specialised structures such as tight junctions(TJs) and adherens junctions (AJs...
Journal Articles
J Cell Sci (2002) 115 (6): 1099–1105.
Published: 15 March 2002
... of the neutrophil oxidase complex. * Author for correspondence (e-mail: chris.ellson@bbsrc.ac.uk ) © The Company of Biologists Limited 2002 2002 Phox PI3-kinase PtdIns(3) P Trafficking NADPH oxidase SNX Phosphoinositide levels are exquisitely regulated within cells and constitute...
Journal Articles
J Cell Sci (2001) 114 (20): 3619–3629.
Published: 15 October 2001
... and was inhibited by 3-methlyadenine, a classical inhibitor of the autophagic pathway. Additionally, wortmannin, an inhibitor of PI3-kinases that blocks autophagy at an early stage, inhibited the accumulation of MDC in autophagic vacuoles. We also found that treatment of the cells with N-ethylmaleimide (NEM...
Journal Articles
Journal Articles
J Cell Sci (1995) 108 (1): 225–233.
Published: 1 January 1995
...-kinase) ( Eberle et al., 1990 ). PI3-kinase is a dimer consisting of a regulatory 85 kDa subunit that asso-ciates with activated tyrosine kinase receptors through its src homologous (SH2) domains and a 110 kDa subunit that encodes the catalytic activity ( Carpenter and Cantley, 1990 ; Panayotou...