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Keywords: PI3-kinase
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Journal Articles
J Cell Sci (2014) 127 (14): 3104–3115.
Published: 15 July 2014
... stimulates lipid droplet formation by activating the long-chain fatty acid receptor FFAR4, which signals through a pertussis-toxin-sensitive G-protein signalling pathway involving phosphoinositide 3-kinase (PI3-kinase), AKT (also known as protein kinase B) and phospholipase D (PLD) activities. This initial...
Journal Articles
J Cell Sci (2012) 125 (2): 340–349.
Published: 15 January 2012
... ‡ Author for correspondence ( makihori@tll.org.sg ) 11 8 2011 © 2012. 2012 Erythroblast enucleation PI3-kinase Microtubules Cell polarization In the last step of erythropoiesis, mammalian erythroblasts undergo enucleation, a process that is crucial for the formation of mature...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (21): 3589–3597.
Published: 1 November 2008
... gradient (less than 5% concentration difference across the cell), PtdIns(3,4,5) P 3 is still somewhat enriched at the leading edge. Cells lacking PI3-kinase (PI3K) activity exhibit poor chemotaxis in these shallow gradients. Owing to the reduced speed and diminished orientation of the cells in steep...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2004) 117 (10): 2037–2049.
Published: 15 April 2004
... endothelial cells fail to undergo vascular assembly and migration in response to ephrin-A1 in vitro. Ephrin-A1 stimulation induces PI3-kinase-dependent activation of Rac1 in wild-type endothelial cells, whereas EphA2-deficient cells fail to activate Rac1 upon stimulation. Expression of dominant negative PI3...
Journal Articles
J Cell Sci (2003) 116 (7): 1187–1197.
Published: 1 April 2003
... with vectors expressing antisense gastrin (ASG), induced significant changes in the subcellular localisation and association of AJ and TJ proteins, and profoundly affected cell adhesion and motility. We also identified the involvement of Src, phosphatidylinositol 3-kinase (PI3-kinase) and protein kinase Cα...
Journal Articles
J Cell Sci (2002) 115 (6): 1099–1105.
Published: 15 March 2002
... of the neutrophil oxidase complex. * Author for correspondence (e-mail: chris.ellson@bbsrc.ac.uk ) © The Company of Biologists Limited 2002 2002 Phox PI3-kinase PtdIns(3) P Trafficking NADPH oxidase SNX Phosphoinositide levels are exquisitely regulated within cells and constitute...
Journal Articles
J Cell Sci (2001) 114 (20): 3619–3629.
Published: 15 October 2001
... and was inhibited by 3-methlyadenine, a classical inhibitor of the autophagic pathway. Additionally, wortmannin, an inhibitor of PI3-kinases that blocks autophagy at an early stage, inhibited the accumulation of MDC in autophagic vacuoles. We also found that treatment of the cells with N-ethylmaleimide (NEM...