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Keywords: PI3-kinase
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Lipid biology
J Cell Sci (2014) 127 (14): 3104–3115.
Published: 15 July 2014
... stimulates lipid droplet formation by activating the long-chain fatty acid receptor FFAR4, which signals through a pertussis-toxin-sensitive G-protein signalling pathway involving phosphoinositide 3-kinase (PI3-kinase), AKT (also known as protein kinase B) and phospholipase D (PLD) activities. This initial...
Journal Articles
J Cell Sci (2012) 125 (2): 340–349.
Published: 15 January 2012
... and PI3K signaling in a manner mechanistically similar to directed cell locomotion. Erythroblast enucleation PI3-kinase Microtubules Cell polarization In the last step of erythropoiesis, mammalian erythroblasts undergo enucleation, a process that is crucial for the formation of mature...
Includes: Multimedia, Supplementary data
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J Cell Sci (2002) 115 (6): 1099–1105.
Published: 15 March 2002
... of the neutrophil oxidase complex. * Author for correspondence (e-mail: [email protected] ) © The Company of Biologists Limited 2002 2002 Phox PI3-kinase PtdIns(3) P Trafficking NADPH oxidase SNX Phosphoinositide levels are exquisitely regulated within cells and constitute...
Journal Articles
J Cell Sci (2001) 114 (20): 3619–3629.
Published: 15 October 2001
... and was inhibited by 3-methlyadenine, a classical inhibitor of the autophagic pathway. Additionally, wortmannin, an inhibitor of PI3-kinases that blocks autophagy at an early stage, inhibited the accumulation of MDC in autophagic vacuoles. We also found that treatment of the cells with N-ethylmaleimide (NEM...
Journal Articles
J Cell Sci (2000) 113 (2): 207–214.
Published: 15 January 2000
... of Biologists 2000 PI3-kinase Cytoskeleton PDGF Insulin Phosphoinositide 3´-kinase (PI3-K) activity induced by growth factor activation of several cell surface receptors leads to the production of the membrane lipids phosphatidylinositol-3-phosphate (PtdIns(3)P), PtdIns(3,4)P 2 and PtdIns...
Journal Articles
Journal Articles
J Cell Sci (1995) 108 (1): 225–233.
Published: 1 January 1995
... activation of rho is mediated by a tyrosine kinase. * Author for correspondence 05 07 1994 19 09 1994 © 1995 by Company of Biologists 1995 actin stress fibre membrane ruffle PI3-kinase wortmannin tyrosine kinase The rho-related small GTP-binding proteins play a key...