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Keywords: PDZ domain
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Journal Articles
J Cell Sci (2022) 135 (11): jcs259547.
Published: 31 May 2022
... cell fates and behaviours during development. To transduce canonical Wnt signals, Dishevelled binds to the intracellular face of Frizzled through its DEP domain and polymerises through its DIX domain to assemble dynamic signalosomes. Dishevelled also contains a PDZ domain, whose function remains...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (20): 3892–3902.
Published: 15 October 2016
... is essential, whereas its PDZ domain is dispensable, for signalling to β-catenin. Our results imply two mutually exclusive functions of the DEP domain in Wnt signal transduction – binding to Frizzled to recruit Dishevelled to the receptor complex, and dimerising to cross-link DIX domain polymers...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2008) 121 (9): 1349–1355.
Published: 1 May 2008
... components must be correctly positioned in both space and time. Adaptor molecules, which contain protein-interaction domains, are often involved in the assembly of multimeric complexes that organize intracellular signal-transduction pathways. One such protein is syntenin, a PDZ-domain-containing molecule...
Journal Articles
J Cell Sci (2004) 117 (1): 19–29.
Published: 1 January 2004
... Leukocyte-endothelial cell interaction Tight junctions Cell polarity PDZ domain Cell-cell interactions are regulated by adhesion receptors on opposing cells. These receptors are frequently associated at the cytoplasmic surface with signalling molecules that respond to binding of extracellular...
Journal Articles
J Cell Sci (2003) 116 (14): 2895–2906.
Published: 15 July 2003
... monolayers and disruption of polarity in MDCK cysts cultured in collagen. Both phenomena require the last four residues of CRB3. Next, we expressed, in MDCK cells, a dominant-negative Myc-Lin-2–Pals1 chimeric protein, where the PDZ domain of Lin-2 was replaced with that of Pals1. TJ and apical polarity...
Journal Articles
J Cell Sci (2003) 116 (7): 1279–1289.
Published: 1 April 2003
... identified several proteins containing PDZ domains. One of these proteins, MAGI-3, contains a guanylate-kinase-like region, six PDZ and two WW domains. The interaction between RPTPβ and MAGI-3 was confirmed by co-immunoprecipitation and pulldown experiments in transfected cells. Immunofluorescence...
Journal Articles
J Cell Sci (2003) 116 (1): 9–15.
Published: 1 January 2003
... Nitric oxide Heart Protein targeting PDZ domain The free radical gas nitric oxide (NO) is now recognized as a major messenger molecule that has diverse functions throughout the body. Although originally identified as the endothelial-derived relaxing factor( Furchgott and Zawadzki, 1980...
Journal Articles
J Cell Sci (2002) 115 (17): 3497–3508.
Published: 1 September 2002
... insertion into the plasma membrane. Given that a number of studies have demonstrated the importance of PDZ-domain-containing proteins in ion channel trafficking, we set out to investigate how EBP50 influences TRPC4 localization and surface delivery in HEK293 cells. A mutant lacking the PDZ-interacting...
Journal Articles
Journal Articles
J Cell Sci (2000) 113 (11): 1851–1856.
Published: 1 June 2000
... domain, a PDZ domain, a long proline-rich region, and a SAM domain. Binding partners for most of these domains have been identified: for instance, the PDZ domain of Shank proteins interacts with GKAP (a postsynaptic-density protein) as well as several G-protein-coupled receptors. The specific...
Journal Articles
J Cell Sci (1998) 111 (16): 2365–2376.
Published: 15 August 1998
... to the epithelial lateral membrane. * Author for correspondence (E-mail: garner@nrc.uab.edu ) 15 06 1998 30 07 1998 © 1998 by Company of Biologists 1998 Actin Cell-cell contact Cytoskeleton MAGUK PDZ domain Members of the SAP97 family of synapse-associated proteins (SAPs...