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Keywords: PDZ
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Journal Articles
J Cell Sci (2018) 131 (16): jcs218610.
Published: 17 August 2018
... + absorption through inhibition of Na + /H + exchanger 3 (NHE3; also known as SLC9A3). The mechanism(s) by which CT inhibits NHE3 is partially understood, although no drug therapy has been successful at reversing this inhibition. We now describe that CT phosphorylates an amino acid in the PDZ domain of SNX27...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (11): 2518–2527.
Published: 01 June 2014
... transduction components in mouse olfactory neurons, organized through MUPP1. Disruption of the PDZ signaling complex, through use of an inhibitory peptide, strongly impaired odor responses and changed the activation kinetics of olfactory sensory neurons. In addition, our experiments demonstrate that...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (7): 1565–1575.
Published: 01 April 2013
... ) 14 01 2013 © 2013. Published by The Company of Biologists Ltd 2013 Tight junction Zonula occludens Paracellular permeability Actin cytoskeleton MAGUK PDZ The tight junction (TJ) is a membrane-associated complex at the apico-lateral margin of epithelial cells that regulates...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (5): 1235–1246.
Published: 01 March 2012
...Mónica Sala-Valdés; Mónica Gordón-Alonso; Emilio Tejera; Anna Ibáñez; J. Román Cabrero; Angeles Ursa; María Mittelbrunn; Francisco Lozano; Francisco Sánchez-Madrid; María Yáñez-Mó In this study, we describe that the PDZ protein syntenin-1 is a crucial element for the generation of signaling...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (5): 776–788.
Published: 01 March 2011
... functional PX domain that is important for endosome binding, but it is the only sorting nexin with a PDZ domain. We identified SNX27 as a partner of diacylglycerol kinase ζ (DGKζ), a negative regulator of T cell function that metabolises diacylglycerol to yield phosphatidic acid. SNX27 interacts with the...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (12): 2018–2026.
Published: 15 June 2008
... the PDZ domain of Sdt – the binding site of Crb – is required for apical targeting. In adult photoreceptors, by contrast, targeting of Sdt to the stalk membrane, a distinct compartment of the apical membrane between the rhabdomere and the zonula adherens, depends on several domains, and seems to be a...
Journal Articles
J Cell Sci (2006) 119 (21): 4391–4401.
Published: 01 November 2006
... localization of Gliotactin. Surprisingly, Gliotactin localization at the TCJ was independent of its PDZ-binding motif and Gliotactin did not bind directly to Discs large. Therefore Gliotactin and Discs large association is through intermediary proteins at the TCJ. Gliotactin can associate with other septate...
Journal Articles
J Cell Sci (2005) 118 (9): 1945–1956.
Published: 01 May 2005
... subunits most closely related to the mammalian AMPA-type receptors. These subunits are expressed in overlapping sets of interneurons, and contain type-I PDZ binding motifs in their carboxy-terminal cytosolic tail sequences. We report that GLR-1 and GLR-2 may form a heteromeric complex, the localization of...
Journal Articles
J Cell Sci (2002) 115 (10): 2067–2073.
Published: 15 May 2002
... out of 37 Clik1-interacting clones. CLP-36 is a PDZ-LIM protein that localizes to actin stress fibers in nonmuscle cells and associates with α-actinin via its PDZ-domain. The association of CLP-36 with Clik1, in turn, is mediated by the C-terminal part of CLP-36 containing the LIM domain, and...
Journal Articles
J Cell Sci (2001) 114 (18): 3219–3231.
Published: 15 September 2001
...Baruch Z. Harris; Wendell A. Lim PDZ domains are protein-protein recognition modules that play a central role in organizing diverse cell signaling assemblies. These domains specifically recognize short C-terminal peptide motifs, but can also recognize internal sequences that structurally mimic a...