...Madison A. Rogers; Maria B. Campaña; Robert Long; Katherine A. Fantauzzo ABSTRACT Signaling through the platelet-derived growth factor receptors (PDGFRs) plays a critical role in multiple cellular processes during development. The two PDGFRs, PDGFRα and PDGFRβ, dimerize to form homodimers...

... in PDGFRα + fibroblasts and suggests that this mechanism could be targeted in tissue repair and regeneration. Canonical Wnt signaling activation through WNT1 upregulates collagen deposition in the ECM and promotes fibroblast differentiation into myofibroblasts (Akhmetshina et al., 2012). Similarly, TGF-β...

...Ditte L. Clement; Sabine Mally; Christian Stock; Mette Lethan; Peter Satir; Albrecht Schwab; Stine F. Pedersen; Søren T. Christensen Summary In fibroblasts, platelet-derived growth factor receptor alpha (PDGFRα) is upregulated during growth arrest and compartmentalized to the primary cilium. PDGF...

... and collagen type-I-producing cells (fibrosis) is observed in muscular dystrophies. The origin of these cells had been largely unknown, but recently we identified mesenchymal progenitors positive for platelet-derived growth factor receptor alpha (PDGFRα) as the origin of adipocytes in skeletal muscle. However...