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Keywords: PDGF
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Journal Articles
J Cell Sci (2019) 132 (16): jcs231639.
Published: 16 August 2019
....   44 , 307 - 314 . 10.1042/BST20150248 Hawkins , P. T. , Eguinoa , A. , Qiu , R.-G. , Stokoe , D. , Cooke , F. T. , Walters , R. , Wennström , S. , Claesson-Welsh , L. , Evans , T. , Symons , M. , et al. ( 1995 ). PDGF stimulates an increase in GTP...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (22): 4228–4238.
Published: 15 November 2009
... and CrkL. We used gene silencing combined with mutational analysis to probe the role of Crk adaptors in platelet-derived growth-factor receptor β (PDGFβR) signaling. We demonstrate that Crk adaptors are required for formation of focal adhesions, and for PDGF-stimulated remodeling of the actin cytoskeleton...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (5): 748–757.
Published: 1 March 2007
... investigated the activation of Src or Fyn by tau, both in vitro and in vivo. Tau increased the kinase activity in in vitro assays and in transfected COS7 cells. In platelet-derived growth factor (PDGF)-stimulated fibroblasts, tau appeared to prime Src for activation following PDGF stimulation, as reflected...
Journal Articles
J Cell Sci (2006) 119 (16): 3316–3324.
Published: 15 August 2006
... formation and decreased Rac activation following PDGF treatment. In addition, we describe a novel interaction between palladin and Eps8, a receptor tyrosine kinase (RTK) substrate that participates in the activation of the Rac-specific guanine nucleotide-exchange function of Sos-1. Eps8 was identified...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (14): 2921–2934.
Published: 15 July 2006
...Laurence Veracini; Mélanie Franco; Anthony Boureux; Valérie Simon; Serge Roche; Christine Benistant The mechanism by which the Src family of protein-tyrosine kinases (SFKs) regulate mitogenesis and morphological changes induced by platelet-derived growth factor (PDGF) is not well known...
Journal Articles
J Cell Sci (2005) 118 (19): 4405–4413.
Published: 1 October 2005
... with platelet-derived growth factor (PDGF). The enzymatic activity of PLD1 was stimulated by adding PtdIns(3,4,5) P 3 in vitro. Treatment with PDGF resulted in the significant increase of PLD1 activity and phosphorylation of the downstream extracellular signal-regulated kinases (ERKs), which was blocked by pre...
Journal Articles
J Cell Sci (2005) 118 (16): 3759–3768.
Published: 15 August 2005
...Mitsunobu R. Kano; Yasuyuki Morishita; Caname Iwata; Shigeru Iwasaka; Tetsuro Watabe; Yasuyoshi Ouchi; Kohei Miyazono; Keiji Miyazawa Combined stimulation with VEGF-A, FGF-2, or PDGF-BB has emerged as a potent strategy for therapeutic angiogenesis, although the mechanisms underlying the synergism...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2004) 117 (22): 5447–5455.
Published: 15 October 2004
... (PtdIns) 3-kinase, actin cytoskeletal remodeling and the v-SNARE VAMP2. The growth factor PDGF-BB also robustly activates PtdIns 3-kinase and induces actin remodeling, raising the question of whether it uses similar mechanisms to insulin in mobilizing GLUT4. In L6 myoblasts stably expressing Myc-tagged...
Journal Articles
J Cell Sci (2004) 117 (1): 93–103.
Published: 1 January 2004
... molecule (PSA-NCAM) in the directional migration of OPCs towards platelet-derived growth factor (PDGF). Using a Boyden microchemotaxis chamber and the Dunn direct viewing chamber, we show that in concentration gradients of PDGF, PSA-positive OPCs polarize and efficiently migrate towards the source of PDGF...
Journal Articles
J Cell Sci (2003) 116 (12): 2443–2451.
Published: 15 June 2003
...Inés M. Antón; Stephen P. Saville; Michael J. Byrne; Claudia Curcio; Narayanaswamy Ramesh; John H. Hartwig; Raif S. Geha Platelet-derived growth factor (PDGF) is a chemotactic factor for fibroblasts that triggers actin cytoskeleton reorganization by increasing the level of GTP-Rac, the activated...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2003) 116 (10): 2015–2028.
Published: 15 May 2003
... and expressed cartilage-specific genes in 7 to 16 day pellet cultures. Depositions of cartilage matrix and type II collagen were detected by day 14. TGFβ-stimulated chondrogenesis was synergistically enhanced by PDGF-BB,resulting in a larger cartilage particle filled with a cartilaginous area containing type II...
Journal Articles
J Cell Sci (1991) 1991 (Supplement_15): 117–123.
Published: 1 February 1991
... oligodendrocytes. In this article we summarize evidence that platelet-derived growth factor (PDGF) is important for stimulating O-2A progenitor cell proliferation in vivo , and describe our efforts to map the distribution of PDGF and its receptors in the developing rat CNS by in situ hybridization...