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Keywords: PCLX-001
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Journal Articles
HIV-1 N-myristoylation-dependent hijacking of late endosomes/lysosomes to drive Gag assembly in macrophages
Open AccessGabriel I. Guajardo-Contreras, Ana L. Abdalla, Alex Chen, Meijuan Niu, Erwan Beauchamp, Luc G. Berthiaume, Alan W. Cochrane, Andrew J. Mouland
Journal:
Journal of Cell Science
J Cell Sci (2024) 137 (22): jcs263588.
Published: 21 November 2024
... revealed that HIV-1 repositions LELs towards the plasma membrane and modulates their motility. We showed that Arl8b-mediated LEL repositioning is not responsible for Gag trafficking to VCCs. Additionally, the inhibition of myristoylation by PCLX-001 decreased the presence of Gag on endosomes and inhibited...
Includes: Supplementary data
