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Keywords: PARP-1
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Journal Articles

A balanced pyrimidine pool is required for optimal Chk1 activation to prevent ultrafine anaphase bridge formation

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Simon Gemble, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Denis Biard, Sarah Lambert, Mounira Amor-Guéret
Journal: Journal of Cell Science
J Cell Sci (2016) 129 (16): 3167–3177.
https://doi.org/10.1242/jcs.187781
Published: 15 August 2016
...Simon Gemble; Géraldine Buhagiar-Labarchède; Rosine Onclercq-Delic; Denis Biard; Sarah Lambert; Mounira Amor-Guéret ABSTRACT Cytidine deaminase (CDA) deficiency induces an excess of cellular dCTP, which reduces basal PARP-1 activity, thereby compromising complete DNA replication, leading...
View articletitled, A balanced pyrimidine pool is required for optimal Chk1 activation to prevent ultrafine anaphase bridge formation
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Includes: Supplementary data
Journal Articles

Gain-of-function of poly(ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: implications for apoptosis

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Damien D’Amours, Frédéric R. Sallmann, Vishva M. Dixit, Guy G. Poirier
Journal: Journal of Cell Science
J Cell Sci (2001) 114 (20): 3771–3778.
https://doi.org/10.1242/jcs.114.20.3771
Published: 15 October 2001
...Damien D’Amours; Frédéric R. Sallmann; Vishva M. Dixit; Guy G. Poirier Poly(ADP-ribosyl)ation is an important mechanism for the maintenance of genomic integrity in response to DNA damage. The enzyme responsible for poly(ADP-ribose) synthesis, poly(ADP-ribose) polymerase 1 (PARP-1), has been...
View articletitled, Gain-of-function of poly(ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: implications for apoptosis
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Journal Articles

Segregation of nucleolar components coincides with caspase-3 activation in cisplatin-treated HeLa cells

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Marcel Horký, Gabriele Wurzer, Vladimír Kotala, Milan Anton, Bólivoj Vojtěsěk, Jiří Vácha, Jozefa Wesierska-Gadek
Journal: Journal of Cell Science
J Cell Sci (2001) 114 (4): 663–670.
https://doi.org/10.1242/jcs.114.4.663
Published: 15 February 2001
...-ribose) polymerase-1 (PARP-1). The caspase-9 activation seems to be mediated by recruitment by the activating factor Apaf-1 because the increased accumulation of Apaf-1 and cytochrome C in cytosol preceded the generation of mature caspase-9 form. A second phase of apoptosis occurring between 10 and 15...
View articletitled, Segregation of nucleolar components coincides with caspase-3 activation in cisplatin-treated HeLa cells
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