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Keywords: PARP
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Journal Articles
J Cell Sci (2020) 133 (12): jcs245811.
Published: 23 June 2020
.... Although the cellular triggers of disease pathology remain enigmatic, mounting evidence implicates the poly(ADP-ribose) polymerases (PARPs) in TDP-43 neurotoxicity. Here we show that inhibition of the PARP enzymes tankyrase 1 and tankyrase 2 (referred to as Tnks-1/2) protect primary rodent neurons from TDP...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (4): 889–903.
Published: 15 February 2013
... complexes, is recruited to DSBs in a poly(ADP-ribose) polymerase 1 (PARP1)-dependent manner. Remarkably, PARP activity, although dispensable for the efficient spreading of γH2AX into damaged chromatin, selectively promotes spreading of SMARCA5, the E3 ubiquitin ligase RNF168, ubiquitin conjugates...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (24): 4481–4491.
Published: 15 December 2009
... inactivation of the molecular necrosis switch PARP-1 and results in apoptosis. By contrast, in the absence of Bak and Bax, a failure to activate caspases results in PARP-1-mediated ATP depletion. The subsequent necrosis is not prevented by autophagy as an alternative energy source. Moreover, in cells deficient...
Includes: Supplementary data
Journal Articles
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J Cell Sci (2009) 122 (12): 1990–2002.
Published: 15 June 2009
...) for their support. References Aguilar-Quesada, R., Munoz-Gamez, J. A., Martin-Oliva, D., Peralta, A., Valenzuela, M. T., Matinez-Romero, R., Quiles-Perez, R., Menissier-de Murcia, J., de Murcia, G., de Almodovar, M. R. et al. ( 2007 ). Interaction between ATM and PARP-1 in response to DNA damage...
Includes: Multimedia, Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2005) 118 (3): 589–599.
Published: 1 February 2005
... carcinogenesis is increased by an inhibitor of the DNA damage-activated nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP), hence PARP activation is likely to be associated with cellular responses that suppress carcinogenesis. To understand the role of activated PARP in these cellular functions, we need...
Journal Articles
J Cell Sci (2004) 117 (6): 815–825.
Published: 22 February 2004
... 2004 2004 PARP PARG poly(ADP-ribose) poly(ADP-ribosyl)ation chromatin histones The nuclear genome of eukaryotes is compacted roughly 40,000-fold ( van Holde, 1988 ). The first level of folding, which produces a 7-fold compaction ratio ( Wolffe, 1998 ), is achieved by formation...
Journal Articles
Journal Articles