.... , Wang   Q. J. , Hu   H. S. , Yu   P. C. , Zhu   J. , Drewes   G. , Piwnica-Worms   H. , Luo   Z. G. ( 2006 ). Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity.   Proc. Natl. Acad. Sci...

... activation. Taken together, these data reveal a role for Baz/Par3 in the establishment of an intercellular gradient of Rac inhibition, from apical to basal, and an intimate association between different apically concentrated Par proteins and Rho-family GTPases in the regulation of the distribution...

...Yosuke Horikoshi; Atsushi Suzuki; Tomoyuki Yamanaka; Kazunori Sasaki; Keiko Mizuno; Hajime Sawada; Shigenobu Yonemura; Shigeo Ohno The evolutionarily conserved polarity proteins PAR-3, atypical protein kinase C (aPKC) and PAR-6 critically regulate the apical membrane development required...

... in epithelial polarization. * Author for correspondence (e-mail: [email protected] ) 12 5 2008 © The Company of Biologists Limited 2008 2008 PAR aPKC Actin dynamics Adherens junction Epithelial cells Polarity Epithelial cells develop a set of characteristic cell...

... with another polarity-regulating protein machinery, the apical PAR-3-aPKC-PAR-6 complex, in epithelial cells. However, the mechanism of Lgl-mediated regulation of epithelial cell polarity remains obscure. By an siRNA method, we here show that endogenous Lgl is required for the disassembly of apical membrane...

...Atsushi Suzuki; Shigeo Ohno Ten years ago, par-1 and par-3 were cloned as two of the six par genes essential for the asymmetric division of the Caenorhabditis elegans zygote. PAR-1 is a protein kinase, whereas PAR-3 is a PDZ-domain-containing scaffold protein. Work over the past decade has shown...

... report that, in addition to their previous described staining patterns, both proteins localise to a focus within the portion of the pseudoautosomal region (PAR) that contains the steroid sulphatase ( Sts ) gene. In light of the timing of its appearance and of its behaviour in sex-chromosomally variant...