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1-13 of 13
Keywords: PAK
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Journal Articles
Shingo Koinuma, Misa Miyaji, Suzuka Akiyama, Yasuyuki Ito, Hiroshi Takemura, Naoyuki Wada, Michihiro Igarashi, Takeshi Nakamura
Journal:
Journal of Cell Science
J Cell Sci jcs.263636.
Published: 29 January 2025
... neurons than in wild-type neurons. Further, TC10 deletion significantly reduced PAK2 autophosphorylation. PAK2 was found on Rab11-positive endosomes in cell bodies and axons, and its localization to endosomes was reduced by TC10 loss. PAK inhibition reduced tubulin acetylation and JNK phosphorylation...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2024) 137 (21): jcs261948.
Published: 13 November 2024
... to vacuole inheritance by preventing premature Vac17 degradation. Organelle inheritance Spindle position checkpoint SPOC p21-activated kinase PAK Vacuole Peroxisome University of Sheffield http://dx.doi.org/10.13039/501100000858 149647784 Saudi Arabia Cultural Bureau...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2019) 132 (10): jcs217869.
Published: 21 May 2019
... important and complex these regulations can be during epithelial morphogenesis. This complexity is mirrored by the fact that Cdc42 can exert its function through many effector proteins. In epithelial cells, these include atypical PKC (aPKC, also known as PKC-3), the P21-activated kinase (PAK) family...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2010) 123 (10): 1663–1673.
Published: 15 May 2010
... J. R. W. , Jones G. E. , Wells C. M. ( 2008 ). A PAK4-LIMK1 pathway drives prostate cancer cell migration downstream of HGF . Cell. Signal. 20 , 1320 - 1328 . Arias-Romero L. E. , Chernoff J. ( 2008 ). A tale of two Paks . Biol. Cell 100 , 97 - 108...
Includes: Multimedia, Supplementary data
Journal Articles
Wonshill Koh, Kamakshi Sachidanandam, Amber N. Stratman, Anastasia Sacharidou, Anne M. Mayo, Eric A. Murphy, David A. Cheresh, George E. Davis
Journal:
Journal of Cell Science
J Cell Sci (2009) 122 (11): 1812–1822.
Published: 1 June 2009
..., but not Fyn or Lyn, results in significant inhibition of EC lumen formation. Concurrent with Cdc42 activation, PKCϵ- and SFK-dependent signaling converge to activate p21-activated kinase (Pak)2 and Pak4 in steps that are also required for EC lumen formation. Pak2 and Pak4 further activate two Raf kinases, B...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2008) 121 (17): 2805–2813.
Published: 1 September 2008
... was mediated in part by Pak. Elucidation of this novel pathway for regulation of the fascin/PKCγ complex in migrating carcinoma cells suggests novel targets for therapeutic intervention in metastasis. * Authors for correspondence (e-mail: [email protected] ; [email protected] ) 13 5 2008...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2008) 121 (7): 989–1001.
Published: 1 April 2008
... that control the signaling events mediating the crucial lumen formation step in vascular morphogenesis. * Author for correspondence (e-mail: [email protected] ) 21 12 2007 © The Company of Biologists Limited 2008 2008 EC lumen formation Rho GTPases Pak Polarity PKC...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2008) 121 (7): 933–938.
Published: 1 April 2008
... Ciencias Naturales, CSIC, 28006 Madrid, Spain 14 1 2008 © The Company of Biologists Limited 2008 2008 Rac small GTPase E-cadherin PAK Cell-cell adhesion Keratinocytes E-cadherin is one of the most important cell-cell adhesion receptors involved in tissue morphogenesis...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2006) 119 (17): 3583–3592.
Published: 1 September 2006
... ). Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (γ-PAK). J. Muscle Res. Cell Motil. 19 , 839 -854. Devreotes, P. and Janetopoulos, C. ( 2003 ). Eukaryotic chemotaxix: distinctions between directional sensing and polarization. J. Biol. Chem. 278 , 20445 -20448...
Includes: Multimedia, Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2001) 114 (23): 4239–4251.
Published: 1 December 2001
...Cheng-Gee Koh; Ed Manser; Zhou-Shen Zhao; Chee-Peng Ng; Louis Lim PIX is a Rho-family guanine nucleotide exchange factor that binds PAK. We previously described two isoforms of PIX that differ in their N termini. Here, we report the identification of a new splice variant of βPIX, designated β2PIX...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2001) 114 (11): 1973–1980.
Published: 1 June 2001
... for correspondence (e-mail: [email protected] ) © The Company of Biologists Limited 2001 2001 GTPase Rho family Actin Rac Pak Dock Kalirin The development of the embryonic nervous system requires that nascent axons extend across a complex extracellular terrain in order to reach...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2000) 113 (3): 471–482.
Published: 1 February 2000
...Qi Zeng; David Lagunoff; Ruthann Masaracchia; Zoe Goeckeler; Graham Côté; Robert Wysolmerski ABSTRACT The p21-activated kinase (PAK) family includes several enzyme isoforms regulated by the GTPases Rac1 and Cdc42. PAK1, found in brain, muscle and spleen, has been implicated in triggering...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1998) 111 (16): 2433–2443.
Published: 15 August 1998
... antibodies (all at 1 μg/ml) for detection of endogenous cortactin; microinjected cells expressing myc-tagged recombinant proteins were detected by double labeling with 9E10 (1:500). In transfected cells coexpressing both myc Rac1N17 and myc PAK1 mutants, PAK1 was detected with polyclonal anti-PAK C-19 (1:500...