... migration, but a molecular role for FAK in promoting cell polarity remains undefined. Here, using wound healing and Golgi-reorientation analyses, we show that fibroblast, endothelial and carcinoma polarity during cell migration requires FAK and is associated with a complex between FAK, p120RasGAP...

... inhibiting R-Ras function through phosphorylation, Eph receptors can reduce R-Ras activity through the GTPase-activating protein, p120RasGAP. By using R-Ras mutants that cannot be inactivated by p120RasGAP and/or cannot be phosphorylated at tyrosine 66, we show that the two forms of R-Ras negative regulation...

... fiber disassembly. The current study seeks to directly test this hypothesis. Tyrosine phosphorylation-regulated association between p190RhoGAP and p120RasGAP has been speculated to serve as a link between the Ras and Rho signaling pathways. In support of this idea, it has been observed...