... controls miRNA-mediated repression and miRNA export. miRNA Processing bodies P-body Mitochondria Polysome Extracellular vesicles Exosomes eIF4E mTORC1 Department of Scientific and Industrial Research, Ministry of Science and Technology, India 10.13039/501100001408 SJF/LS-03/2014...

...Jieshuang Jia; Elisabeth Werkmeister; Sara Gonzalez-Hilarion; Catherine Leroy; Dieter C. Gruenert; Frank Lafont; David Tulasne; Fabrice Lejeune ABSTRACT Nonsense-mutation-containing messenger ribonucleoprotein particles (mRNPs) transit through cytoplasmic foci called P-bodies before undergoing...

...Adva Aizer; Alon Kalo; Pinhas Kafri; Amit Shraga; Rakefet Ben-Yishay; Avi Jacob; Noa Kinor; Yaron Shav-Tal ABSTRACT The 5′-to-3′ mRNA degradation machinery localizes to cytoplasmic processing bodies (P-bodies), which are non-membranous structures found in all eukaryotes. Although P-body function...

... translocates to the P-body, where mRNA degradation, translational repression and mRNA surveillance take place. Depletion of Lats2 or 14-3-3γ by siRNA inhibits P-body formation in response to UV, newly implicating Lats2 and 14-3-3 as regulators of P-body formation. By contrast, siRNA-mediated depletion of Lats1...

...Mariela Loschi; Claudia C. Leishman; Neda Berardone; Graciela L. Boccaccio Stress granules (SGs) and P-bodies (PBs) are related cytoplasmic structures harboring silenced mRNAs. SGs assemble transiently upon cellular stress, whereas PBs are constitutive and are further induced by stress. Both foci...