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1-12 of 12
Keywords: P-bodies
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Journal Articles
Disruption of ER–mitochondria contact sites induces autophagy-dependent loss of P-bodies through the Ca 2+ -CaMKK2-AMPK pathway
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2025) 138 (5): JCS263652.
Published: 12 March 2025
...Nikhil More; Jomon Joseph ABSTRACT P-bodies (PBs) and stress granules (SGs) are conserved, non-membranous cytoplasmic condensates of RNA–protein complexes. PBs are implicated in post-transcriptional regulation of gene expression through mRNA decay, translational repression and/or storage. Although...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2024) 137 (4): jcs261326.
Published: 22 February 2024
.... Oxidative stress-induced AGS3 BMCs were distinct from G3BP1 stress granules and from RNA processing BMCs defined by the P-body protein Dcp1a. Immunoblots indicated that cellular stress shifted AGS3, but not the stress granule protein G3BP1 to a membrane pellet fraction following cell lysis. The stress...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism
Journal:
Journal of Cell Science
J Cell Sci (2021) 134 (24): jcs259117.
Published: 16 December 2021
...-bodies), which are cytoplasmic ribonucleoprotein granules that store translationally repressed mRNA. IP6K1 does not localise to P-bodies, but instead binds to ribosomes, where it interacts with the mRNA decapping complex – the scaffold protein EDC4, activator proteins DCP1A/B, decapping enzyme DCP2...
Includes: Supplementary data
Journal Articles
Takahiro Hamada, Mako Yako, Marina Minegishi, Mayuko Sato, Yasuhiro Kamei, Yuki Yanagawa, Kiminori Toyooka, Yuichiro Watanabe, Ikuko Hara-Nishimura
Journal:
Journal of Cell Science
J Cell Sci (2018) 131 (16): jcs216051.
Published: 20 August 2018
... formation is not correlated with the sizes of pre-existing RNA processing bodies (P-bodies) but that the two structures often associated rapidly. Immunoelectron microscopy revealed a previously unidentified characteristic of the fine structures of Arabidopsis stress granules and P-bodies: the lack...
Includes: Supplementary data
Journal Articles
Overexpression of MLN51 triggers P-body disassembly and formation of a new type of RNA granules
FreeNicolas Cougot, Élisabeth Daguenet, Aurélie Baguet, Annie Cavalier, Daniel Thomas, Pascale Bellaud, Alain Fautrel, Florence Godey, Édouard Bertrand, Catherine Tomasetto, Reynald Gillet
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (21): 4692–4701.
Published: 1 November 2014
.... In this study, we further investigated the cytoplasmic role of MLN51. We show that MLN51 is a new component of processing bodies (P-bodies). When overexpressed, MLN51 localizes in novel small cytoplasmic foci. These contain RNA, show directed movements and are distinct from stress granules and P-bodies...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2013) 126 (9): 2114–2123.
Published: 1 May 2013
... mRNA compartmentalization or degradation. Here we report that processing bodies (P-bodies), which are involved in mRNA degradation or storage, are transported to dendrites by conventional kinesin (KIF5A) as a motor protein. Neuronal activation induced by depolarization increased the colocalization of P...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2012) 125 (12): 2896–2909.
Published: 15 June 2012
... that the accumulation of newly synthesised partially processed mRNAs results in the formation of foci around the periphery of the nucleus. These nuclear periphery granules (NPGs) contain the full complement of P-body proteins identified in trypanosomes to date, as well as poly(A)-binding protein 2 and the trypanosome...
Includes: Supplementary data
Journal Articles
Stress-specific composition, assembly and kinetics of stress granules in Saccharomyces cerevisiae
Free
Journal:
Journal of Cell Science
J Cell Sci (2011) 124 (2): 228–239.
Published: 15 January 2011
...J. Ross Buchan; Je-Hyun Yoon; Roy Parker Eukaryotic cells respond to cellular stresses by the inhibition of translation and the accumulation of mRNAs in cytoplasmic RNA–protein (ribonucleoprotein) granules termed stress granules and P-bodies. An unresolved issue is how different stresses affect...
Includes: Multimedia, Supplementary data
Journal Articles
Tomáš Groušl, Pavel Ivanov, Ivana Frydlová, Pavla Vašicová, Filip Janda, Jana Vojtová, Kateřina Malínská, Ivana Malcová, Lenka Nováková, Dana Janošková, Leoš Valášek, Jiří Hašek
Journal:
Journal of Cell Science
J Cell Sci (2009) 122 (12): 2078–2088.
Published: 15 June 2009
... P-body markers also colocalized with eIF3a. Microscopic analyses of the edc3 Δ lsm4 ΔC mutant demonstrated that different scaffolding proteins are required to induce SGs upon robust heat shock as opposed to glucose deprivation. Even though eIF2α became phosphorylated under these stress conditions...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2008) 121 (19): 3253–3260.
Published: 1 October 2008
... the transported ribonucleoparticle (RNP), control mRNA stability and local translation. Recently, the existence of processing bodies (P-bodies), in which mRNA decapping and degradation take place, was revealed in neurons. It was suggested that P-bodies serve as a transient storage compartment for mRNAs, which can...
Journal Articles
Susanne Kramer, Rafael Queiroz, Louise Ellis, Helena Webb, Jörg D. Hoheisel, Christine Clayton, Mark Carrington
Journal:
Journal of Cell Science
J Cell Sci (2008) 121 (18): 3002–3014.
Published: 15 September 2008
... of P-body-like granules that contained DHH1, SCD6 and XRNA, (3) the formation of stress granules that remained largely separate from the P-body-like granules and localise to the periphery of the cell and, (4) an increase in the size of a novel focus located at the posterior pole of the cell...
Includes: Supplementary data
Journal Articles
Andrew Jakymiw, Kaleb M. Pauley, Songqing Li, Keigo Ikeda, Shangli Lian, Theophany Eystathioy, Minoru Satoh, Marvin J. Fritzler, Edward K. L. Chan
Journal:
Journal of Cell Science
J Cell Sci (2007) 120 (8): 1317–1323.
Published: 15 April 2007
...Andrew Jakymiw; Kaleb M. Pauley; Songqing Li; Keigo Ikeda; Shangli Lian; Theophany Eystathioy; Minoru Satoh; Marvin J. Fritzler; Edward K. L. Chan GW bodies, also known as mammalian P-bodies, are cytoplasmic foci involved in the post-transcriptional regulation of eukaryotic gene expression...