... into the effects of iron and prolyl hydroxylase on oxygen sensing. The model advances quantitative molecular level understanding of HIF1 pathways - an endeavor that will help elucidate the diverse responses to hypoxia found in cancer, ischemia and exercise. In vitro studies have shown how the hypoxic response...

..., for example, inducible nitric oxide synthase, and virtually all glycolytic enzymes. Thus the induction of HIF-1α is central for the adaptation of cells, tissues and the whole organism to hypoxia. Hypoxia Oxygen sensing Hypoxia inducible factor Hydroxylase © The Company of Biologists Limited...