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Keywords: Oxidative stress
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Journal Articles
J Cell Sci (2020) 133 (21): jcs247304.
Published: 09 November 2020
... that the E3 ubiquitin–protein ligase RNF144a promotes the degradation of VRK3 via polyubiquitylation and thus affects VRK3-mediated ERK activity. Under oxidative stress, VRK3 migrates from the nucleus to the cytoplasm, which increases its chance of interacting with RNF144a, thereby promoting the degradation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs245589.
Published: 09 July 2020
...Saloni Agarwal; Subramaniam Ganesh ABSTRACT The heat shock response (HSR) is a conserved cellular defensive response against stresses such as temperature, oxidative stress and heavy metals. A significant group of players in the HSR is the set of molecular chaperones known as heat shock proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (9): jcs236943.
Published: 11 May 2020
... advanced our understanding of the biology, physiology and consequences of functional defects in peroxisomes. In this Review, we discuss a cooperative cell defense mechanisms against oxidative stress that involves the localization of BAK (also known as BAK1) to peroxisomes, which alters peroxisomal membrane...
Journal Articles
In collection:
Mitochondria
J Cell Sci (2019) 132 (22): jcs233783.
Published: 20 November 2019
... in cellular ATP levels and mitochondrial respiration are observed in condensin II CAP subunit-deficient cells. Surprisingly, we find that loss of NCAPD3 also sensitizes cells to oxidative stress. Together, these studies identify new, and possibly independent, roles for condensin II CAP subunits in preventing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (12): jcs214726.
Published: 25 June 2018
... D1 prevents cancer cells from undergoing senescence, at least partially, by keeping the level of intracellular oxidative stress at a tolerable sub-lethal level. Depletion of cyclin D1 promotes the RB-independent pro-senescence pathway and the cancer cells then succumb to the endogenous oxidative...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (6): jcs212506.
Published: 21 March 2018
...Wen Shi; Manuel A. Riquelme; Sumin Gu; Jean X. Jiang ABSTRACT Elevated oxidized stress contributes to lens cataracts, and gap junctions play important roles in maintaining lens transparency. As well as forming gap junctions, connexin (Cx) proteins also form hemichannels. Here, we report a new...
Journal Articles
J Cell Sci (2016) 129 (2): 314–328.
Published: 15 January 2016
... phosphorylation Oxidative stress Nucleus Cell cortex Annexin A2 (AnxA2) is a multifunctional protein and a member of the annexin superfamily of proteins initially characterised by their Ca 2+ - and lipid-binding properties ( Gerke and Moss, 2002 ; Moss and Morgan, 2004 ; Gerke et al., 2005 ; Singh...
Journal Articles
J Cell Sci (2014) 127 (6): 1327–1335.
Published: 15 March 2014
...Alan J. Weids; Chris M. Grant ABSTRACT Peroxiredoxins are ubiquitous thiol-specific proteins that have multiple functions in stress protection, including protection against oxidative stress. Tsa1 is the major yeast peroxiredoxin and we show that it functions as a specific antioxidant to protect...
Journal Articles
J Cell Sci (2013) 126 (14): 3141–3150.
Published: 15 July 2013
... pore complex (NPC), form S–S bonds and regulate nuclear transport through the NPC. Kinetic analysis of importin β demonstrated that the permeability of the NPC was increased by dithiothreitol treatment and reduced by oxidative stress. The permeability of small proteins such as GFP was not affected...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (6): 1488–1497.
Published: 15 March 2013
... response to oxidative stress, and highlight the importance of such mechanisms in the oocyte in order to protect the embryo from paternally mediated genetic damage. * Author for correspondence ( john.aitken@newcastle.edu.au ) 12 01 2013 © 2013. Published by The Company of Biologists Ltd...
Journal Articles
J Cell Sci (2012) 125 (10): 2407–2415.
Published: 15 May 2012
... countries. Although pathogenic factors, such as oxidative stress, inflammation and genetics are thought to contribute to the development of AMD, little is known about the relationships and priorities between these factors. Here, we show that chronic photo-oxidative stress is an environmental factor involved...
Journal Articles
J Cell Sci (2012) 125 (4): 1015–1026.
Published: 15 February 2012
.... , Rutkowski L. H. , Strich R. ( 2003 ). Ask10p mediates the oxidative stress-induced destruction of the Saccharomyces cerevisiae C-type cyclin Ume3p/Srb11p . Eukaryot. Cell 2 , 962 - 970 . Collart M. A. ( 2003 ). Global control of gene expression in yeast by the Ccr4-Not complex...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (15): 2672–2679.
Published: 01 August 2010
...Timothy J. Tavender; Neil J. Bulleid Disulphide formation within the endoplasmic reticulum (ER) requires the activity of the ER oxidase Ero1, and as a consequence, generates hydrogen peroxide. The production of hydrogen peroxide is thought to lead to oxidative stress that ultimately results...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (21): 3851–3855.
Published: 01 November 2009
... ; Omary et al., 2009 ). Intermediate filaments Keratin 8 Keratin 18 Cytoprotection Mitochondria Liver injury Apoptosis Cytochrome c release Oxidative stress © The Company of Biologists Limited 2009 2009 25 8 2009 * Author for correspondence ( mbishr@umich.edu...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (10): 1518–1528.
Published: 15 May 2009
... intracellular ROS through interaction of its structurally defined N-terminal polybasic region with cell-surface proteoglycans. * Author for correspondence (e-mail: stevenjc@unimelb.edu.au ) 10 1 2009 © The Company of Biologists Limited 2009 2009 Prion N-terminus Oxidative stress...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (7): 919–928.
Published: 01 April 2009
... by pharmacological inhibitors blocked PKD1 activation under oxidative stress. To date it has been viewed that monosaturated and saturated DAG formed via PLD1 have no signaling function. However, our data describe a role for PLD1-induced DAG as a competent second messenger at the mitochondria that relays ROS to PKD1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (4): 563–573.
Published: 15 February 2009
... and are in dynamic equilibrium with translating polysomes. Mammalian Staufen 1 (Stau1) is a ubiquitous double-stranded RNA-binding protein associated with polysomes. Here, we show that Stau1 is recruited to stress granules upon induction of endoplasmic reticulum or oxidative stress as well in stress granules induced...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (7): 1046–1053.
Published: 01 April 2008
... for a telomere-independent survival function of telomerase. However, its mechanism is not understood. We show here that TERT, the catalytic subunit of human telomerase, protects human fibroblasts against oxidative stress. While TERT maintains telomere length under standard conditions, telomeres under increased...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (20): 3666–3677.
Published: 15 October 2007
... stress. In endothelial cells, oxidative stress quickly activates the extracellular-signal-regulated kinase (ERK) MAP kinase, which results in the phosphorylation of tropomyosin. Here, we investigated further the mechanisms of tropomyosin phosphorylation and its function in actin remodeling. We identified...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (13): 2284–2294.
Published: 01 July 2007
... 2007 © The Company of Biologists Limited 2007 2007 p53 SiHa H 2 O 2 ROS Oxidative stress RNA interference (RNAi) Reactive oxygen species (ROS) such as superoxide, hydroxyl and peroxyl radicals, and hydrogen peroxide (H 2 O 2 ) are more reactive than molecular oxygen...