... apoptosis inducer, but also suggest a potential impact of Bok expression in ovarian cancer therapy. References Beroukhim , R. , Mermel , C. H. , Porter , D. , Wie , G. , Raychaudhuri , S. , Donovan , J. , Barretina , J. , Boehm , J. S. , Dobson , J. , Urashima...

... tumor metastasis in part by promoting EMT in cancer cells. The underlying mechanism whereby hypoxia orchestrates EMT remains poorly defined. Here we report that SIRT1, a multifaceted player in tumorigenesis, opposed ovarian cancer metastasis in vitro and in vivo by impeding EMT. Hypoxic stress...

... with the extracellular microenvironment and invasion of secondary sites. There is a compelling need to tailor new, physiologically relevant in silico models that are specialised for particular types of cancer, such as ovarian cancer owing to its unique route of metastasis, which are capable of investigating anti-cancer...

...). DNAs were identified through DNA sequencing (Dye Terminator ABI Type Seq., Bionex, Seoul, South Korea). Human ovarian cancer (PA-1, SKOV3), human cervical cancer (HeLa), CHO-KI and COS-7 cells (Chinese hamster ovary and African green monkey kidney, respectively) were purchased from American Type...

... ligand, Nodal, induce apoptosis in human epithelial ovarian cancer cells. In this study, we examined the regulation of ALK7 by miRNAs and demonstrate that miR-376c targets ALK7. Ectopic expression of miR-376c significantly increased cell proliferation and survival, enhanced spheroid formation and blocked...

..., the precursors of ovarian carcinoma. Conversely, overexpression of p53 by adenoviral infection and activation of p53 by γ-irradiation both diminished p110α protein levels in normal OSE and ovarian cancer cells. The demonstration that p53 binds directly to the PIK3CA promoter and inhibits its activity identifies...