... activity can cause bone defects, in particular their hyper-activation is commonly associated with many pathologies, hormonal imbalance and medical treatments. Increased bone degradation by osteoclasts provokes progressive bone loss, leading to osteoporosis, with the resulting bone frailty leading...

... in the pathogenesis of osteoporosis and attenuates osteogenesis by inhibiting differentiation of osteoblasts through ERK1/2 signaling. Osteoblast CXCL2 Osteoporosis Bone formation Differentiation ERK1/2 National Natural Science Foundation of China 10.13039/501100001809 81672120 81700783...

... for bone-loss diseases such as osteoporosis. This article has an associated First Person interview with the first author of the paper. * Author for correspondence ( [email protected] ) Competing interests The authors declare no competing or financial interests. 16 7 2018 21 9 2018...

[email protected] ) Competing interests The authors declare no competing or financial interests. 19 05 2014 2 02 2015 © 2015. Published by The Company of Biologists Ltd 2015 BMP Activin BMPR2 Bone mass Osteoblast Osteoporosis References Allendorph   G. P. , Vale...

...-mediated Bim down-regulation through induction of microRNA-181a.   Blood   116 , 5228 – 5236 . 10.1182/blood-2010-03-275925 Manolagas   S. C. ( 2000 ). Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis.   Endocr. Rev...

... ), raising the possibility that lack of cadherin 11 might be compensated for by another member of this superfamily – the most likely candidate being N-cadherin. Cell-cell adhesion Osteoporosis Bone remodeling Osteoblast differentiation © 2010. 2010 26 4 2010 * Author...

... and shared significantly reduced longitudinal bone growth. Mutant long bones were characterised by reduced numbers of growth plate chondrocytes and a severe osteoporosis. Decreased JunB levels in epiphysal growth plate chondrocytes and bone lining osteoblasts correlated with deregulated expression of Cyclin...