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Keywords: Osteopetrosis
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J Cell Sci (2021) 134 (9): jcs254979.
Published: 11 May 2021
...) and induces autosomal recessive osteopetrosis in humans and in mice. We show here that the fusion of wild-type murine monocytes to form OCLs is highly regulated, and that its extent is limited by blocking fusion between mature OCLs. In contrast, monocytes from homozygous R51Q SNX10 mice fuse uncontrollably...
Includes: Supplementary data
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J Cell Sci (2016) 129 (4): 693–705.
Published: 15 February 2016
... proliferator-activated receptor gamma (PPARγ, also known as PPARG) in mice leads to osteopetrosis and pulmonary arterial hypertension. Vascular disease is associated with loss of PPARγ in pulmonary microvascular endothelial cells (PMVEC); we evaluated the role of PPARγ in PMVEC functions, such as angiogenesis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (22): 3811–3821.
Published: 15 November 2011
... that whereas deletion of Rac1 or Rac2 alone has no effect, variable reduction of Rac1 in osteoclastic cells of Rac2 −/− mice causes severe osteopetrosis. Osteoclasts lacking Rac1 and Rac2 in combination (Rac double-knockout, RacDKO), fail to effectively resorb bone. By contrast, osteoclasts are abundant...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (1993) 104 (4): 1021–1029.
Published: 1 April 1993
... colony stimulating factor (M-CSF or CSF-1) because of the recessive osteopetrotic (op/op) mutation. Prior work had shown that osteopetrosis is associated with a lack of osteoclasts, phagocytic cells required for remodelling in bone. Additional macrophage populations proved to be very M-CSF dependent. op...