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Keywords: Osteoclast
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Journal Articles
J Cell Sci (2021) 134 (22): jcs259040.
Published: 26 November 2021
...Sarah Klapproth; Karsten Richter; Clara Türk; Theresa Bock; Thomas Bromberger; Julian Dominik; Kathrin Huck; Kristian Pfaller; Michael W. Hess; Christoph A. Reichel; Marcus Krüger; Inaam A. Nakchbandi; Markus Moser ABSTRACT Osteoclasts form special integrin-mediated adhesion structures called...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (9): jcs254979.
Published: 11 May 2021
...Maayan Barnea-Zohar; Sabina E. Winograd-Katz; Moran Shalev; Esther Arman; Nina Reuven; Lee Roth; Ofra Golani; Merle Stein; Fadi Thalji; Moien Kanaan; Jan Tuckermann; Benjamin Geiger; Ari Elson ABSTRACT Homozygosity for the R51Q mutation in sorting nexin 10 (SNX10) inactivates osteoclasts (OCLs...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs244798.
Published: 1 July 2020
...Anne Blangy; Guillaume Bompard; David Guerit; Pauline Marie; Justine Maurin; Anne Morel; Virginie Vives ABSTRACT Osteoclasts are giant multinucleated myeloid cells specialized for bone resorption, which is essential for the preservation of bone health throughout life. The activity of osteoclasts...
Journal Articles
J Cell Sci (2020) 133 (10): jcs239772.
Published: 27 May 2020
...David Guérit; Pauline Marie; Anne Morel; Justine Maurin; Christel Verollet; Brigitte Raynaud-Messina; Serge Urbach; Anne Blangy ABSTRACT Among hematopoietic cells, osteoclasts (OCs) and immature dendritic cells (DCs) are closely related myeloid cells with distinct functions: OCs participate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (10): jcs229351.
Published: 15 May 2019
...Dinisha Cyril Pirapaharan; Jacob Bastholm Olesen; Thomas Levin Andersen; Sandra Bjerre Christensen; Per Kjærsgaard-Andersen; Jean-Marie Delaisse; Kent Søe ABSTRACT Osteoblast lineage cells in human bone were recently shown to colonize eroded bone surfaces and to closely interact with osteoclasts...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2017) 130 (12): 2026–2035.
Published: 15 June 2017
...Kent Søe; Jean-Marie Delaissé ABSTRACT Bone erosion both demands that the osteoclast resorbs bone matrix and moves over the bone surface. It is widely accepted that these two activities alternate, because they are considered mutually exclusive since resorption is believed to involve an immobilizing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (18): 3449–3461.
Published: 15 September 2016
...Heiani Touaitahuata; Anne Morel; Serge Urbach; Julio Mateos-Langerak; Sylvain de Rossi; Anne Blangy ABSTRACT Bone resorption by osteoclasts is mediated by a typical adhesion structure called the sealing zone or actin ring, whose architecture is based on a belt of podosomes. The molecular mechanisms...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (18): 3411–3419.
Published: 15 September 2015
.... Here, we investigated its functional relevance during osteoclast differentiation. KCNK1 was significantly induced during osteoclast differentiation, but its functional overexpression significantly inhibited osteoclast differentiation induced by RANKL (also known as TNFSF11), which was accompanied...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (4): 683–694.
Published: 15 February 2015
...Tristan W. Fowler; Archana Kamalakar; Nisreen S. Akel; Richard C. Kurten; Larry J. Suva; Dana Gaddy ABSTRACT The process of osteoclastic bone resorption is complex and regulated at multiple levels. The role of osteoclast (OCL) fusion and motility in bone resorption are unclear, with the movement...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (7): 1666–1672.
Published: 1 April 2012
... the temporal molecular steps of the de novo assembly and disassembly of podosomes in cultured osteoclasts. We demonstrate here that the earliest visible step in podosome assembly is the local accumulation of the plaque protein paxillin, along with cortactin, which stabilizes actin networks, followed by robust...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2012) 125 (3): 662–672.
Published: 1 February 2012
...Jiro Takito; Masanori Nakamura; Masaki Yoda; Takahide Tohmonda; Shinichi Uchikawa; Keisuke Horiuchi; Yoshiaki Toyama; Kazuhiro Chiba Multinucleated osteoclasts are responsible for bone resorption. Hypermultinucleated osteoclasts are often observed in some bone-related diseases such as Paget's...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (22): 3811–3821.
Published: 15 November 2011
...Monica Croke; F. Patrick Ross; Matti Korhonen; David A. Williams; Wei Zou; Steven L. Teitelbaum Cdc42 mediates bone resorption principally by stimulating osteoclastogenesis. Whether its sister GTPase, Rac, meaningfully impacts upon the osteoclast and, if so, by what means, is unclear. We find...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (9): 1503–1510.
Published: 1 May 2010
...Dafna Geblinger; Lia Addadi; Benjamin Geiger Bone resorption by osteoclasts depends on the assembly of a specialized, actin-rich adhesive ‘sealing zone’ that delimits the area designed for degradation. In this study, we show that the level of roughness of the underlying adhesive surface has...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (15): 2555–2564.
Published: 1 August 2008
...Eun-Ju Chang; Jeongim Ha; Hao Huang; Hyung Joon Kim; Jung Hoon Woo; Youngkyun Lee; Zang Hee Lee; Ju Han Kim; Hong-Hee Kim Osteoclastogenesis involves the commitment of macrophage-lineage precursors to tartrate-resistant acid phosphatase-positive (TRAP + ) mononuclear pre-osteoclasts (pOCs...
Journal Articles
J Cell Sci (2007) 120 (13): 2162–2170.
Published: 1 July 2007
... activation by TNF-alpha to osteoclastic or cytocidal phenotype. J. Immunol. 165 , 4957 -4963. Fuller, K., Lean, J. M., Bayley, K. E., Wani, M. R. and Chambers, T. J. ( 2000 ). A role for TGFbeta(1) in osteoclast differentiation and survival. J. Cell Sci. 113 , 2445 -2453. Gazit, D...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (1): 166–176.
Published: 1 January 2007
...Eun-Ju Chang; Hyon Jong Kim; Jeongim Ha; Hyung Joon Kim; Jiyoon Ryu; Kwang-Hyun Park; Uh-Hyun Kim; Zang Hee Lee; Hyun-Man Kim; David E. Fisher; Hong-Hee Kim The differentiation of osteoclasts, cells specialized for bone resorption, is governed by two key factors, macrophage colony stimulating...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (23): 4878–4888.
Published: 1 December 2006
...Chen Luxenburg; J. Thomas Parsons; Lia Addadi; Benjamin Geiger Osteoclasts are large, multinucleated cells that adhere to bone via podosomes, and degrade it. During osteoclast polarization, podosomes undergo reorganization from a scattered distribution, through the formation of clusters and ring...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (7): 1283–1296.
Published: 1 April 2006
... on their anabolic effects acting on cells of the osteoblast lineage. In this study we provide evidence that Wnts also regulate osteoclast formation and bone resorption, through a mechanism involving transcriptional repression of the gene encoding the osteoclastogenic cytokine receptor activator of NFκB ligand...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (23): 5479–5487.
Published: 1 December 2005
...Beatrice B. Yaroslavskiy; Yongjun Zhang; Sara E. Kalla; Verónica García Palacios; Allison C. Sharrow; Yanan Li; Mone Zaidi; Chuanyue Wu; Harry C. Blair The osteoclast degrades bone in cycles; between cycles, the cell is motile. Resorption occurs by acid transport into an extracellular compartment...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2001) 114 (15): 2775–2786.
Published: 1 August 2001
...Martin Pfaff; Pierre Jurdic Macrophages and osteoclasts develop unique contact sites with the extracellular matrix called podosomes. Podosomes have been associated with migratory and invasive cell characteristics, but a basic mechanism outlining their function is lacking. We have used chicken...