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Keywords: Osteoblast
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Journal Articles
J Cell Sci (2021) 134 (1): jcs251645.
Published: 11 January 2021
...Leyao Shen; Deepika Sharma; Yilin Yu; Fanxin Long; Courtney M. Karner ABSTRACT Osteoblasts are the principal bone-forming cells. As such, osteoblasts have enhanced demand for amino acids to sustain high rates of matrix synthesis associated with bone formation. The precise systems utilized by...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (22): jcs231993.
Published: 14 November 2019
...Ana S. Brandão; Anabela Bensimon-Brito; Raquel Lourenço; Jorge Borbinha; Ana Rosa Soares; Rita Mateus; António Jacinto ABSTRACT Osteoblast differentiation is a key process for bone homeostasis and repair. Multiple signalling pathways have been associated with osteoblast differentiation, yet much...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (16): jcs230490.
Published: 27 August 2019
... have not yet been reported. We report here that CXCL2 is enriched in bone marrow and show abundant expression of CXCL2 in osteoblasts of osteoporotic mice. CXCL2 neutralization within the bone marrow by using antibody alleviated bone loss in mice, indicating a negative role of CXCL2 in bone formation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (1): jcs207001.
Published: 04 January 2018
...Caroline Moerke; Susanne Staehlke; Henrike Rebl; Birgit Finke; J. Barbara Nebe ABSTRACT The topographical and chemical surface features of biomaterials are sensed by the cells, affecting their physiology at the interface. When placed on titanium, we recently discovered osteoblasts attempted...
Journal Articles
J Cell Sci (2017) 130 (3): 531–540.
Published: 01 February 2017
...Megan C. Moorer; Carla Hebert; Ryan E. Tomlinson; Shama R. Iyer; Max Chason; Joseph P. Stains ABSTRACT In skeletal tissue, loss or mutation of the gap junction protein connexin 43 (Cx43, also known as GJA1) in cells of the osteoblast lineage leads to a profound cortical bone phenotype and defective...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (5): 1018–1030.
Published: 01 March 2016
...Masaki Ishikawa; Geneva L. Williams; Tomoko Ikeuchi; Kiyoshi Sakai; Satoshi Fukumoto; Yoshihiko Yamada ABSTRACT Pannexin 3 (Panx3) and connexin 43 (Cx43; also known as GJA1) are two major gap junction proteins expressed in osteoblasts. Here, we studied their functional relationships in skeletal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (7): 1308–1315.
Published: 01 April 2015
...@hsdm.harvard.edu ) Competing interests The authors declare no competing or financial interests. 19 05 2014 2 02 2015 © 2015. Published by The Company of Biologists Ltd 2015 BMP Activin BMPR2 Bone mass Osteoblast Osteoporosis We next performed western blots on...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (17): 3711–3719.
Published: 01 September 2014
...Takao Hirai; Kenjiro Tanaka; Akifumi Togari ABSTRACT The sympathetic nervous system modulates bone remodeling and mediates the expression of core clock genes in part through the β-adrenergic receptor (β-AR) in osteoblasts. In this study, we show that in MC3T3-E1 osteoblastic cells that...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (24): 5598–5609.
Published: 15 December 2013
...Valerie S. Salazar; Nicholas Zarkadis; Lisa Huang; Marcus Watkins; Jacqueline Kading; Sheri Bonar; Jin Norris; Gabriel Mbalaviele; Roberto Civitelli Summary Canonical Wnt (cWnt) signaling through β-catenin regulates osteoblast proliferation and differentiation to enhance bone formation. We...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (21): 4974–4984.
Published: 01 November 2013
... pathway, in Osx1 + cells in mice. We show that loss of Smad4 causes stunted growth, spontaneous fractures and a combination of features seen in osteogenesis imperfecta, cleidocranial dysplasia and Wnt-deficiency syndromes. Bones of Smad4 mutant mice exhibited markers of fully differentiated osteoblasts...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (22): 5564–5577.
Published: 15 November 2012
... murine embryonic stem cells (ESCs) under culture conditions that promote osteogenesis. Expression profiles of NO pathway members and osteoblast-specific markers were analyzed using appropriate assays. We found that NO was supportive of osteogenesis specifically during an early phase of in vitro...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (9): 2160–2171.
Published: 01 May 2012
... ectopically expressing TNF-α [human TNF transgenic ( hTNF tg) mice]. The phenotype is associated with a decrease in bone formation because of fewer osteoblasts as well as a drastically increased bone destruction by osteoclasts. The molecular basis of this phenotype is a cell autonomous increased sensitivity...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (5): 682–689.
Published: 01 March 2010
..., differentiation and function from multiple receptors. However, its biological role in osteoblast activity and postnatal bone metabolism remains unclear. To elucidate the in vivo function of Gab1 in postnatal bone remodeling, we generated osteoblast-specific Gab1 knockout mice. Disruption of Gab1 expression in...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (22): 4160–4167.
Published: 15 November 2009
... and its downstream molecule Akt (also known as PKB). We propose that LAR functions as a negative regulator of adipogenesis. Furthermore, our data support the possibility that LAR controls the balance between osteoblast and adipocyte differentiation. Overall, our findings contribute to the...
Journal Articles
J Cell Sci (2009) 122 (19): 3566–3578.
Published: 01 October 2009
... studies were performed using bone marrow stromal (BMS) cells isolated from 6-month-old WT and Axin2 KO mice. Osteoblast proliferation and differentiation were significantly increased and osteoclast formation was significantly reduced in Axin2 KO mice. Nuclear β-catenin protein levels were significantly...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (5): 716–726.
Published: 01 March 2009
... bone-specific transcription factors. In a mesenchymal stem cell model of osteoblast commitment and differentiation controlled by BMP2, we show that an inhibitor of PI3-kinase or a dominant-negative Akt were as potent in preventing osteoblast differentiation as the IGF binding protein IGFBP5, whereas a...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (15): 2565–2573.
Published: 01 August 2007
...Md. Moksed Ali; Tatsuya Yoshizawa; Osamu Ishibashi; Akio Matsuda; Mika Ikegame; Junko Shimomura; Hisashi Mera; Kazuhisa Nakashima; Hiroyuki Kawashima We recently reported that tensile stress induces osteoblast differentiation and osteogenesis in the mouse calvarial suture in vitro. Using this...
Journal Articles
J Cell Sci (2007) 120 (13): 2162–2170.
Published: 01 July 2007
... maintaining bone homeostasis, we disrupted the Smad4 gene in differentiated osteoblasts using the Cre-loxP system. The Smad4 mutant mice exhibited lower bone mass up to 6 months of age. The proliferation and function of the mutant osteoblasts were significantly decreased. Bone mineral density, bone volume...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (7): 1216–1224.
Published: 01 April 2007
... Protein phosphatase Osteoblast Growth factors of the TGFβ superfamily regulate cell proliferation, differentiation, migration and apoptosis and are crucial for the development and maintenance of many different tissues ( Cheifetz, 1999 ; Francis-West et al., 1999 ). Bone morphogenetic proteins...
Journal Articles
J Cell Sci (2006) 119 (7): 1283–1296.
Published: 01 April 2006
... on their anabolic effects acting on cells of the osteoblast lineage. In this study we provide evidence that Wnts also regulate osteoclast formation and bone resorption, through a mechanism involving transcriptional repression of the gene encoding the osteoclastogenic cytokine receptor activator of...
Includes: Supplementary data