...: Organ-on-chip culture models are emerging in vitro experimental systems for biological discovery in the context of tissue morphogenesis. Cell and developmental biology Microphysiological systems Organoids Organ-on-chip Tissue morphogenesis National Institutes of Health http...

... and organoids from patients harboring mucinous colorectal carcinoma (MUC CRC), a poor-prognosis histological form of digestive cancer, to study the architecture, invasive behavior and chemoresistance of tumor cell intermediates. We report that these tumors maintain a robust apico-basolateral polarity...

... drives intestinal epithelia tumorigenesis. Exuberant cell proliferation is one well-established consequence of oncogenic Wnt pathway activity; however, the contribution of other deregulated molecular circuits to tumorigenesis has not been fully examined. Using in vivo and organoid models of intestinal...