... polarity Hinge point LGL Midbrain Neural tube closure defects Organogenesis PAR3 Many tubular organs develop from flat epithelial sheets that are invaginated and rolled to form closed tubes ( Andrew and Ewald, 2010 ; Martin-Belmonte et al., 2008 ; Pilot and Lecuit, 2005 ). Invagination...

... Organogenesis aPKC Mpp5 Pals1 Lin-7 Crumbs Par6 Cell polarity and maintenance of epithelial integrity are tightly linked to many developmental processes including the establishment of transepithelial diffusion barriers within gut and epidermis, as well as the morphogenesis of complex organs...

...-mail: [email protected] ) © The Company of Biologists Limited 2003 2003 Embryo Organogenesis Development Asymmetry Monocilia Polycystin Nearly all organs of the thorax and abdomen are left-right (LR) asymmetric in anatomy, placement and, in some cases, physiology. LR asymmetry itself...