... and target Rab27a. Organelle transport Guanine nucleotide exchange factor Rab27a Rab3GEP MADD Melanocyte Medical Research Council G1100063 Wellcome Trust 10.13039/100010269 091346/Z/10/Z 108429/Z/15/Z University of Nottingham 10.13039/501100000837...

...Christopher L. Robinson; Richard D. Evans; Deborah A. Briggs; Jose S. Ramalho; Alistair N. Hume ABSTRACT Microtubules and F-actin, and their associated motor proteins, are considered to play complementary roles in long- and short-range organelle transport. However, there is growing appreciation...

..., as they facilitate an experimental dissection of organelle transport and retention processes. Much progress has been made in defining the molecular players involved in organelle partitioning in yeast. Each organelle uses a distinct set of factors – motor, anchor and adaptor proteins – that ensures its inheritance...

...Anna S. Serpinskaya; Karine Tuphile; Leonard Rabinow; Vladimir I. Gelfand ABSTRACT Regulation of organelle transport along microtubules is important for proper distribution of membrane organelles and protein complexes in the cytoplasm. RNAi-mediated knockdown in cultured Drosophila S2 cells...

...Ayumu Yamamoto; Yasushi Hiraoka Cytoplasmic dynein is a microtubule motor that mediates various biological processes, including nuclear migration and organelle transport, by moving on microtubules while associated with various cellular structures. The association of dynein with cellular structures...

... distribution, short directed movements of melanosomes in the cell cortex observed in MT-depleted wild type melanocytes,were absent in melanocytes of dilute mice( Wu et al., 1998 ). Secretory granules Myosin Va hCgB-GFP Cell cortex F-actin Organelle transport © The Company of Biologists...

...Shuo Ma; Rex L. Chisholm Intracellular organelle transport is driven by motors that act upon microtubules or microfilaments. The microtubulebased motors, cytoplasmic dynein and kinesin, are believed to be responsible for retrograde and anterograde transport of intracellular cargo along microtubules...

...Olga C. Rodriguez; Richard E. Cheney Class V myosins are one of the most ancient and widely distributed groups of the myosin superfamily and are hypothesized to function as motors for actin-dependent organelle transport. We report the discovery and initial characterization of a novel member...

... Organelle transport In animal cells, transport of organelles and maintenance of their organization and position in the cytoplasm depends mostly on microtubule-based motor proteins: kinesins and dyneins. With few exceptions, kinesins move cargoes towards the plus-ends of microtubules, while dyneins...

... of conventional kinesins ( Lehmler et al., 1997 ). These motors are thought to be involved in organelle transport (summarized by Schroer and Sheetz, 1991 ; Bloom and Endow, 1994 ), but their specific functions in living cells have remained elusive. The deletion of kin2 from U. maydis did not affect...

...L. L. Evans; A. J. Lee; P. C. Bridgman; M. S. Mooseker ABSTRACT Myosin-V has been linked to actin-based organelle transport by a variety of genetic, biochemical and localization studies. However, it has yet to be determined whether myosin-V functions as an organelle motor. To further investigate...

...Robert J. Pelham, Jr; Jim Jung-Ching Lin; Yuli Wang ABSTRACT Although nonmuscle tropomyosins (TM) have been implicated in various cellular functions, such as stabilization of actin filaments and possibly regulation of organelle transport, their physiological role is still poorly understood. We have...