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Keywords: Orai1
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Journal Articles
J Cell Sci (2022) 135 (5): jcs258579.
Published: 22 June 2021
...+ entry in many different cell types. The CRAC channel is composed of the plasma membrane (PM)-localized Orai1 channel and endoplasmic reticulum (ER)-localized STIM1 Ca 2+ sensor. Upon ER Ca 2+ store depletion, Orai1 and STIM1 form complexes at ER–PM junctions, leading to the formation of activated CRAC...
Includes: Supplementary data
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J Cell Sci (2021) 134 (2): jcs248658.
Published: 27 January 2021
... Stim1 oligomerization and its activation of Orai. Ca 2+ GPN LMP Orai1 Stim1 Lysosome Membrane-permeant lysosomotropic agents have long been used to disrupt lysosomal function and include two distinct classes: peptides or cationic amphiphilic drugs. Peptides such as glycyl-L...
Includes: Supplementary data
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J Cell Sci (2020) 133 (1): jcs237354.
Published: 8 January 2020
... spontaneous SOCE via binding to the coiled-coil domain retaining hydrophobic interaction between CCα1 and CC3. Ca 2+ signaling STIM1 Orai1 Store-operated Ca 2+ entry SOCE IDstim National Research Foundation of Korea 10.13039/501100003725 2016H1A2A1909031 NRF-2018R1A5A1024340 NRF...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (1): jcs240358.
Published: 3 January 2020
...Dalia Alansary; Diana B. Peckys; Barbara A. Niemeyer; Niels de Jonge ABSTRACT ORAI1 proteins form highly selective Ca 2+ channels in the plasma membrane. Crystallographic data point towards a hexameric stoichiometry of ORAI1 channels, whereas optical methods postulated ORAI1 channels to reside...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (10): jcs226019.
Published: 15 May 2019
...-401L and MEG-01 cells resulted in a reduction in STIM1 tyrosine phosphorylation, SOCE and the Ca 2+ release-activated Ca 2+ current ( I CRAC ). STIM1–Orai1 colocalization was reduced in HEK293 cells transfected with YFP–STIM1-Y316F compared to in cells with wild-type (WT) YFP-tagged STIM1. Additionally...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (17): 2821–2832.
Published: 1 September 2017
...Marek K. Korzeniowski; Eva Wisniewski; Barbara Baird; David A. Holowka; Tamas Balla ABSTRACT Decreased luminal endoplasmic reticulum (ER) Ca 2+ concentration triggers oligomerization and clustering of the ER Ca 2+ sensor STIM1 to promote its association with plasma membrane Orai1 Ca 2+ channels...
Includes: Supplementary data
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Journal Articles
J Cell Sci (2013) 126 (11): 2401–2410.
Published: 1 June 2013
... through intricate coordination between the Ca 2+ sensor on the ER membrane (stromal interaction molecule 1, STIM1) and the plasma membrane channel Orai1. When Ca 2+ stores are depleted, STIM1 oligomerizes and physically interacts with Orai1 through its SOAR/CAD domain, resulting in Orai1 gating and Ca 2...
Journal Articles
J Cell Sci (2013) 126 (7): 1672–1681.
Published: 1 April 2013
... is downregulated during mouse meiosis, but remains active in mature metaphase II eggs. SOCE inhibition is due to a decreased ability of the Ca 2+ sensor STIM1 to translocate to the cortical endoplasmic reticulum domain and due to internalization of Orai1. Reversing SOCE downregulation by overexpression of STIM1...
Includes: Supplementary data
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Journal Articles
J Cell Sci (2012) 125 (2): 287–294.
Published: 15 January 2012
...Mirko Völkers; Nima Dolatabadi; Natalie Gude; Patrick Most; Mark A. Sussman; David Hassel Mutations in the store-operated Ca 2+ entry pore protein ORAI1 have been reported to cause myopathies in human patients but the mechanism involved is not known. Cardiomyocytes express ORAI1 but its role...
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Journal Articles
J Cell Sci (2007) 120 (12): 1959–1965.
Published: 15 June 2007
... of store-operated channels. e-mail: [email protected] 19 4 2007 © The Company of Biologists Limited 2007 2007 Store-operated Ca 2+ entry Ca 2+ channels Stim1 Orai1 Ca 2+ -release-activated Ca 2+ current In a variety of cell types, activation of phospholipase C...