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Keywords: Optineurin
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Journal Articles
In collection:
Proteostasis
J Cell Sci (2013) 126 (2): 580–592.
Published: 15 January 2013
...Jelena Korac; Veronique Schaeffer; Igor Kovacevic; Albrecht M. Clement; Benno Jungblut; Christian Behl; Janos Terzic; Ivan Dikic Summary Aggregation of misfolded proteins and the associated loss of neurons are considered a hallmark of numerous neurodegenerative diseases. Optineurin is present...
Journal Articles
J Cell Sci (2012) 125 (21): 5026–5039.
Published: 1 November 2012
... trafficking of transferrin receptor. Optineurin, a Rab8-binding effector protein, mediates the interaction and colocalisation of TBC1D17 with Rab8. A non-catalytic region of TBC1D17 is required for direct interaction with optineurin. Co-expression of Rab8, but not other Rabs tested, rescues the inhibition...
Includes: Supplementary data