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Keywords: Oocyte
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Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (13): jcs260281.
Published: 13 July 2022
...Gaelle Letort; Adrien Eichmuller; Christelle Da Silva; Elvira Nikalayevich; Flora Crozet; Jeremy Salle; Nicolas Minc; Elsa Labrune; Jean-Philippe Wolf; Marie-Emilie Terret; Marie-Hélène Verlhac ABSTRACT Meiotic maturation is a crucial step of oocyte formation, allowing its potential fertilization...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (6): jcs259807.
Published: 23 March 2022
...Kathleen Scheffler; Federica Giannini; Tom Lemonnier; Binyam Mogessie ABSTRACT Formation of healthy mammalian eggs from oocytes requires specialised F-actin structures. F-actin disruption produces aneuploid eggs, which are a leading cause of human embryo deaths, genetic disorders and infertility...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (24): jcs259237.
Published: 20 December 2021
...Anne Bourdais; Benoit Dehapiot; Guillaume Halet ABSTRACT How multiple actin networks coexist in a common cytoplasm while competing for a shared pool of monomers is still an ongoing question. This is exemplified by meiotic maturation in the mouse oocyte, which relies on the dynamic remodeling...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (14): jcs254037.
Published: 23 July 2021
...Janet K. Jang; Amy C. Gladstein; Arunika Das; Joanatta G. Shapiro; Zachary L. Sisco; Kim S. McKim ABSTRACT Meiosis in female oocytes lacks centrosomes, the microtubule-organizing centers. In Drosophila oocytes, meiotic spindle assembly depends on the chromosomal passenger complex (CPC...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (14): jcs256297.
Published: 20 July 2021
...Xiaotian Wang; Claudia Baumann; Rabindranath De La Fuente; Maria M. Viveiros ABSTRACT Oocyte-specific knockdown of pericentrin (PCNT) in transgenic (Tg) mice disrupts acentriolar microtubule-organizing center (aMTOC) formation, leading to spindle instability and error-prone meiotic division. Here...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (13): jcs257956.
Published: 12 July 2021
...Aujan Mehregan; Goli Ardestani; Hiroki Akizawa; Ingrid Carvacho; Rafael Fissore ABSTRACT Ca 2+ influx during oocyte maturation and after sperm entry is necessary to fill the internal Ca 2+ stores and for complete egg activation. We knocked out the transient receptor potential vanilloid member 3...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (23): jcs249128.
Published: 11 December 2020
... of temporal and spatial control of translation remains unclear. In oocytes, many mRNAs are deposited as a translationally repressed form and are translated at appropriate times to promote the progression of meiosis and development. Here, we show that changes in subcellular structures and states of the RNA...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (3): jcs238105.
Published: 10 February 2020
...Yue Wang; Jian Li; Feng Dong; Wei Yue; Ying-Chun Ouyang; Zhen-Bo Wang; Yi Hou; Heide Schatten; Qing-Yuan Sun ABSTRACT Oocyte meiotic maturation failure is one of the major causes for female infertility. Meiotic resumption (the G2/M transition) and progression through metaphase I (MI) are two...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (23): jcs222356.
Published: 5 December 2018
... conserved actin monomer-binding proteins, have been known to promote actin disassembly by enhancing the actin-severing activity of the ADF/cofilin protein family. In this study, we found that CAP1 regulated actin remodeling during mouse oocyte maturation. Efficient actin disassembly during oocyte maturation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (22): jcs218099.
Published: 22 November 2018
...Julia Uraji; Kathleen Scheffler; Melina Schuh ABSTRACT Gametes undergo a specialized and reductional cell division termed meiosis. Female gametes (oocytes) undergo two rounds of meiosis; the first meiotic division produces the fertilizable egg, while the second meiotic division occurs upon...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (10): jcs212522.
Published: 23 May 2018
... dybowskii) oocyte maturation . Gen. Comp. Endocrinol.   109 , 293 - 301 . 10.1006/gcen.1997.7038 Bayaa , M. , Booth , R. A. , Sheng , Y. and Liu , X. J. ( 2000 ). The classical progesterone receptor mediates Xenopus oocyte maturation through a nongenomic mechanism . Proc. Natl...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (19): 3297–3307.
Published: 1 October 2017
... of germ cell survival, oocyte meiotic maturation, and maternal-zygotic transition in mammals. DDB1–cullin-4-associated factor-2 (DCAF2, also known as DTL or CDT2) is an evolutionarily conserved substrate receptor of CRL4. To determine whether DCAF2 is a key CRL4 substrate adaptor in mammalian oocytes, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2416–2429.
Published: 15 July 2017
...Sugako Ogushi; Kazuo Yamagata; Chikashi Obuse; Keiko Furuta; Teruhiko Wakayama; Martin M. Matzuk; Mitinori Saitou ABSTRACT The mammalian oocyte nucleolus, the most prominent subcellular organelle in the oocyte, is vital in early development, yet its key functions and constituents remain unclear. We...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2017) 130 (7): 1251–1262.
Published: 1 April 2017
...Claudia Baumann; Xiaotian Wang; Luhan Yang; Maria M. Viveiros ABSTRACT Mouse oocytes lack canonical centrosomes and instead contain unique acentriolar microtubule-organizing centers (aMTOCs). To test the function of these distinct aMTOCs in meiotic spindle formation, pericentrin (Pcnt...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2016) 129 (19): 3648–3660.
Published: 1 October 2016
...Ahmed Z. Balboula; Alexandra L. Nguyen; Amanda S. Gentilello; Suzanne M. Quartuccio; David Drutovic; Petr Solc; Karen Schindler ABSTRACT Meiotic oocytes lack classic centrosomes and, therefore, bipolar spindle assembly depends on clustering of acentriolar microtubule-organizing centers (MTOCs...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (16): 3153–3166.
Published: 15 August 2016
... transition in oocytes is essential for reproduction. However, the mechanism for threshold establishment is unclear. In starfish oocytes, maturation-inducing hormones activate the PI3K–Akt pathway through the G βγ complex of heterotrimeric G-proteins. Akt directly phosphorylates both Cdc25 phosphatase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (16): 3091–3103.
Published: 15 August 2016
...Jing Guo; Lanying Shi; Xuhong Gong; Mengjie Jiang; Yaoxue Yin; Xiaoyun Zhang; Hong Yin; Hui Li; Chihiro Emori; Koji Sugiura; John J. Eppig; You-Qiang Su ABSTRACT Communication between oocytes and their companion somatic cells promotes the healthy development of ovarian follicles, which is crucial...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (23): 4442–4452.
Published: 1 December 2015
... egg activation requires influx of extracellular Ca 2+ ; however, the channels that mediate this influx remain unknown. Here, we tested whether the α1 subunit of the T-type channel Ca V 3.2, encoded by Cacna1h , mediates Ca 2+ entry into oocytes. We show that mouse eggs express a robust voltage...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (20): 3769–3780.
Published: 15 October 2015
... in female gametogenesis, Ppp6c F/F mice were first generated and crossed with Zp3-Cre mice to selectively disrupt Ppp6c expression in oocytes. Here, we report for the first time that PP6c is dispensable for oocyte meiotic maturation but essential for exit from meiosis II (MII) after fertilization. Depletion...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism
J Cell Sci (2015) 128 (13): 2319–2329.
Published: 1 July 2015
... (PDHE1α, also known as PDHA1) of the pyruvate dehydrogenase (PDH) complex. However, the roles of PDKs in meiotic maturation are currently unknown. Here, by undertaking knockdown and overexpression analysis of PDK paralogs (PDK1–PDK4) in mouse oocytes, we established the site-specificity of PDKs towards...
Includes: Supplementary data