... of the G1 phase of the neuroepithelial cell cycle is a cause, rather than a consequence, of neurogenesis. As an experimental system, we used whole mouse embryo culture, which was found to exactly reproduce the temporal and spatial gradients of the onset of neurogenesis occurring in utero. Olomoucine, a cell...

... -arrested cells and is therefore presumably distinct from the mitosis-promoting Cdc2-cyclin B heterodimer. * Author for correspondence 03 04 1995 11 05 1995 © 1995 by Company of Biologists 1995 apoptosis Cdc2 cell cycle checkpoint mitoxantrone olomoucine Cell...

...Tom Misteli; Graham Warren ABSTRACT Populations enriched in prophase cells were obtained either by using a cell line with a temperature-sensitive mutation in the mitotic kinase, p34 cdc2 , or by treating cells with olomoucine, an inhibitor of this kinase. Both methods resulted in efficient...