... evidence indicates that oligomerization of kindlins might affect their integrin binding and focal adhesion localization, positively or negatively. In this Review, we presented an update on the recent progress of obtaining kindlin structures, and discuss the implication for integrin activation based...

... of fluorescence fluctuation microscopy called two-photon scanning number and brightness (sN&B). We found that dimerization of DLC2 was required for its interaction with GKAP, which, in turn, potentiated GKAP self-association. In the dendritic shaft, the DLC2–GKAP hetero-oligomeric complexes were composed...

... crosslinking and gel filtration assays collectively demonstrate that a RyR2 N-terminal fragment possesses the intrinsic ability to oligomerize, enabling apparent tetramer formation. Interestingly, N-terminus tetramerization mediated by endogenous disulfide bond formation occurs in native RyR2, but notably...

..., their functional importance undergoes pronounced developmental changes. * These authors contributed equally to this work ‡ Author for correspondence ([email protected]) 11 1 2012 © 2012. 2012 G-protein coupled receptor Oligomerization Signal transduction G...

... and functional nature of very large, supermolecular Dvl3-based complexes. * Author for correspondence ([email protected]) 22 7 2010 © 2010. 2010 Dishevelled Oligomerization Supermolecular Complexes Wnt3a Wnt signaling regulates numerous cellular pathways, including...

... control is unclear. Here, we show that a TCRα mutant lacking these intramembrane charged residues has a tendency to form homooligomers through an interchain disulfide bond that involves a specific pair of cysteine residues. Covalent oligomerization of TCRα appears to stabilize it at the ER membrane...

... the predicted oligomerization properties of the transporter; hence, co-immunoprecipitation experiments using differentially tagged transporters showed evidence for oligomerization of both ABCG2-wt and of ABCG2-wt with ABCG2-K86M. We also obtained evidence that both ABCG2-wt and ABCG2-K86M exist in the cells...

..., ERGIC-53, that cycles in the early secretory pathway. ER export requires a phenylalanine motif at the C-terminus, known to mediate coat protein II (COPII) interaction, that is assisted by a glutamine in the cytoplasmic domain. Disulfide bond-stabilized oligomerization is also required. Efficient...

...-containing proteins. Moreover, analyses of recombinant Hrp65 by gel-filtration chromatography show that Hrp65 can not only dimerize but also oligomerize into complexes of at least three to six molecules. Furthermore, we have analyzed the functional significance of the Hrp65 self-interaction in cotransfection...

... to the cell surface and efficient pH-dependent IgG binding. * Author for correspondence (e-mail: [email protected]) 19 3 2002 © The Company of Biologists Limited 2002 2002 Human immunoglobulin G Major histocompatibility complex Endoplasmic reticulum Oligomerization...

... of the extracellular domain of Boss is not sufficient for Sevenless activation, and instead acts as a weak antagonist. Because oligomerization appears to be a critical step in the activation of receptor tyrosine kinases, we used oligomerized forms of the Boss extracellular domain to test their ability to bind...

... of Biologists 1995 tenascin oligomerization disulfide bond extracellular matrix glioma cell Most extracellular matrix proteins are multimeric. A variety of subunit combinations have been described including multimers composed of identical subunits (tenascin (TN), cartilage oligomeric matrix...