...Nicolas Snaidero; Mikael Simons ABSTRACT The myelin sheath is a plasma membrane extension that is laid down in regularly spaced segments along axons of the nervous system. This process involves extensive changes in oligodendrocyte cell shape and membrane architecture. In this Cell Science...

...Dirk Fitzner; Mareike Schnaars; Denise van Rossum; Gurumoorthy Krishnamoorthy; Payam Dibaj; Mostafa Bakhti; Tommy Regen; Uwe-Karsten Hanisch; Mikael Simons The transfer of antigens from oligodendrocytes to immune cells has been implicated in the pathogenesis of autoimmune diseases. Here, we show...

...Christine Winterstein; Jacqueline Trotter; Eva-Maria Krämer-Albers The central nervous system myelin sheath is a multilayered specialized membrane with compacted and non-compacted domains of defined protein composition. How oligodendrocytes regulate myelin membrane trafficking and establish...

...Mikael Simons; Katarina Trajkovic During the development of the central nervous system the reciprocal communication between neurons and oligodendrocytes is essential for the generation of myelin, a multilamellar insulating membrane that ensheathes the axons. Neuron-derived signalling molecules...

...Anja Schneider; Hanna Länder; Giselheid Schulz; Hartwig Wolburg; Klaus-Armin Nave; Jörg B. Schulz; Mikael Simons Myelin is a specialized membrane enriched in glycosphingolipids and cholesterol that contains a restricted set of proteins. The mechanisms by which oligodendrocytes target myelin...

...Martin C. Raff; Laura E. Lillien ABSTRACT In the rat central nervous system (CNS) oligodendrocytes and type-2 astrocytes are thought to develop from a common precursor - the O-2A progenitor cell. Oligodendrocytes develop first and make myelin; type-2 astrocytes develop later and extend processes...