...Zuying Yu; Ruijie Luo; Yutian Li; Xiaoguang Li; Zhengrui Yang; Jiangtong Peng; Kai Huang ABSTRACT Adipogenesis is closely related to various metabolic diseases, such as obesity, type 2 diabetes, cardiovascular diseases and cancer. This cellular process is highly dependent on the expression...

... increases total neurite length. Human obesity-associated variants, when expressed in SH2B1δ, alter neurite complexity, suggesting that a decrease or increase in neurite branching may have deleterious effects that contribute to the severe childhood obesity and neurobehavioral abnormalities associated...

...Jingnan Liu; Xiaobo Wang; Rui Ma; Tianxia Li; Gongbo Guo; Bo Ning; Timothy H. Moran; Wanli W. Smith ABSTRACT Expression of synphilin-1 in neurons induces hyperphagia and obesity in a Drosophila model. However, the molecular pathways underlying synphilin-1-linked obesity remain unclear. Here...

..., such as hematopoietic precursors and lineage-committed cells. In this diverse cellular milieu, bone marrow adipocytes influence commitment decisions and cellular lineage selection by interacting with stem and progenitor cells. In addition, bone marrow adipocytes respond to environmental changes, such as obesity...

... upregulated SREBP-target lipogenic genes and blocked ER stress in the hypothalamus. Furthermore, CNS-specific Tak1 deletion prevented ER-stress-induced hypothalamic leptin resistance and hyperphagic obesity under a high-fat diet (HFD). Thus, TAK1 is a crucial regulator of ER stress in vivo , which could...

... ‐deficient brown adipocytes. Collectively, our study demonstrates a novel temporal regulatory mechanism in fine‐tuning brown adipocyte lineage progression to affect brown fat formation and thermogenic regulation, which could be targeted therapeutically to combat obesity. 13 12 2014 25 2 2015...

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