.... , Schauss , A. C. , Rugarli , E. and Langer , T. ( 2014 ). The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission . J. Cell Biol.   204 , 919 - 929 . 10.1083/jcb.201308006 Biswas , G. , Adebanjo , O. A. , Freedman , B. D...

...Jinliang Nan; Cunjin Nan; Jian Ye; Lu Qian; Ya Geng; Dawei Xing; Muhammad Saif Ur Rahman; Mingyuan Huang ABSTRACT Mitochondria are important for energy production and cardiomyocyte homeostasis. OMA1, a metalloendopeptidase, initiates the proteolytic process of the fusion-allowing protein OPA1...

.... Electron microscopy (EM) analysis of the EDL indicated an overall higher mitochondria content, and increased cristae density in subsarcolemmal and A-band mitochondrial subpopulations. The higher cristae density in Il15ra −/− mitochondria was associated with higher OPA1 and cardiolipin levels. Overall...

...Francesco Consolato; Francesca Maltecca; Susanna Tulli; Irene Sambri; Giorgio Casari ABSTRACT The proteolytic processing of dynamin-like GTPase OPA1, mediated by the activity of both YME1L1 [intermembrane (i)-AAA protease complex] and OMA1, is a crucial step in the regulation of mitochondrial...

...Thomas MacVicar; Thomas Langer ABSTRACT The regulation of mitochondrial dynamics by the GTPase OPA1, which is located at the inner mitochondrial membrane, is crucial for adapting mitochondrial function and preserving cellular health. OPA1 governs the delicate balance between fusion and fission...

... cyanide m -chlorophenyl hydrazone. Mechanistically, we show that this is because cleavage of the inner membrane fusion factor L-OPA1 is prevented due to the failure to activate the inner membrane protease OMA1 in mitochondria that have a collapsed membrane potential. In parallel, mitochondria that use...

... maintenance, and that only the latter function is essential for cell viability. This parallels recent observations that have distinguished the role of OPA1, the human orthologue of Msp1p, in mitochondrial dynamics from that in cristae organization and apoptosis. Furthermore, our observations may contribute...