... sulfation inhibits binding of GPR15L. In contrast, the disruption of O-glycosylation on the N-terminal threonine or serine residues, or the removal of α2,3-linked sialic acids from O-glycans, enhances the GPR15L binding. Thus, GPR15 represents a unique chemoattractant receptor in which different N-terminal...

... was prevented by the presence of O -glycans. Partial FXYD5 deglycosylation enabled antibody binding and showed that the protein level and the degree of O -glycosylation were greater in cancer than in normal cells. FXYD5-induced impairment of adhesion was abolished by both genetic and pharmacological inhibition...

... in vivo . Mutants lacking these histidine residues retain substrates more efficiently. Surprisingly, they are also O-glycosylated and partially secreted. Co-expression of client proteins prevents secretion of the histidine mutants, forcing tail opening and RDEL accessibility. Client-induced RDEL exposure...

... for correspondence 18 03 1994 17 05 1994 © 1994 by Company of Biologists 1994 secretion exocytosis glycoprotein complex O-glycosylation extracellular matrix phosphorylation Dictyostelium discoideum is a widely studied organism in developmental and cell biology. When...

... associated with neoplastic transformation. * Author for correspondence 07 05 1992 17 03 1993 © 1993 by Company of Biologists 1993 O -glycosylation endoplasmic reticulum Golgi apparatus mucin secretory pathway brefeldin A colon cancer Cellular transformation...

...-linked carbohydrate terminating in N -acetylgluco-samine . * Author for correspondence 05 10 1990 30 11 1990 © 1991 by Company of Biologists 1991 p65 protein phosphotyrosine phosphatase O -glycosylation Examination of the histone kinase profiles of human...