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Keywords: Nucleus
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Journal Articles
J Cell Sci (2022) 135 (8): jcs259493.
Published: 3 May 2022
...Sandrine B. Lavenus; Karl W. Vosatka; Alexa P. Caruso; Maria F. Ullo; Ayesha Khan; Jeremy S. Logue ABSTRACT When metastasizing, tumor cells must traverse environments with diverse physicochemical properties. Recently, the cell nucleus has emerged as a major regulator of the transition from...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (6): jcs253021.
Published: 26 March 2021
...Sanju Ashraf; Ye Dee Tay; David A. Kelly; Kenneth E. Sawin ABSTRACT Movement of the cell nucleus typically involves the cytoskeleton and either polymerization-based pushing forces or motor-based pulling forces. In the fission yeast Schizosaccharomyces pombe , nuclear movement and positioning...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (2): jcs247643.
Published: 27 January 2021
... by an increase in H3K27me3 ( Fig. 3 B,C). Interestingly, depletion of Suv39H1 and the subsequent reduced H3K9me3 was sufficient to trigger a decrease in nuclear volume without affecting circularity ( Fig. 3 D), a similar morphological change in the nucleus to that observed in response to HP. Suv39H1 depletion...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (5): jcs252544.
Published: 9 November 2020
... of adenovirus (AdV) infection. AdV delivers, transcribes and replicates a linear double-stranded DNA genome in the nucleus. We measured the abundance of viral transcripts using single-molecule RNA fluorescence in situ hybridization (FISH) and the incoming 5-ethynyl-2′-deoxycytidine (EdC)-tagged viral genomes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (20): jcs254094.
Published: 30 October 2020
...Justin T. Jacob; Raji R. Nair; Brian G. Poll; Christopher M. Pineda; Ryan P. Hobbs; Michael J. Matunis; Pierre A. Coulombe ABSTRACT Keratin 17 ( KRT17 ; K17), a non-lamin intermediate filament protein, was recently found to occur in the nucleus. We report here on K17-dependent differences...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (22): jcs235911.
Published: 14 November 2019
... rate (G,H) of individual time bins from data described in A assigned into cohorts according to the cell (E,F) or nucleus (G,H) volume at the start of the bin. Linear regression lines are shown except for H as r 2 <0.2. (I) Experimental (blue), limiting components model (see Materials and Methods...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (8): jcs226852.
Published: 17 April 2019
...Tiina Viita; Salla Kyheröinen; Bina Prajapati; Jori Virtanen; Mikko J. Frilander; Markku Varjosalo; Maria K. Vartiainen ABSTRACT In addition to its essential functions within the cytoskeleton, actin also localizes to the cell nucleus, where it is linked to many important nuclear processes from gene...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (21): jcs218479.
Published: 29 October 2018
... used experimental systems as well as in vivo . In this Hypothesis, we highlight known examples of intracellular mechanical challenges in biological systems and focus on the coping mechanisms of two important organelles, the nucleus and mitochondria, for they are the best studied in this aspect...
Journal Articles
J Cell Sci (2018) 131 (18): jcs220251.
Published: 20 September 2018
... or their cleaved cytoplasmic domains. In cancer cells, these nuclear functions contribute to tumor progression and drug resistance. Here, we examined whether the single Drosophila EGFR can also localize to the nucleus. A chimeric EGFR protein fused at its cytoplasmic C-terminus to DNA-binding and transcriptional...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (14): jcs216556.
Published: 27 July 2018
...Cédric Yapo; Anu G. Nair; Jeanette Hellgren Kotaleski; Pierre Vincent; Liliana R. V. Castro ABSTRACT Although it is known that protein kinase A (PKA) in the nucleus regulates gene expression, the specificities of nuclear PKA signaling remain poorly understood. Here, we combined computational...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (8): jcs211094.
Published: 13 April 2018
... the nucleus which changes with cell differentiation . Biochem. J.   248 , 765 - 770 . 10.1042/bj2480765 Dieck , C. B. , Wood , A. , Brglez , I. , Rojas-Pierce , M. and Boss , W. F. ( 2012 ). Increasing phosphatidylinositol (4,5) bisphosphate biosynthesis affects plant nuclear...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (17): 2926–2940.
Published: 1 September 2017
... events given that the analysis requires components from many cells. Microscopy can visualize single cells, but the cell body and organelles can hamper staining and visualization of the nucleus. Normally, chromatin is visualized by immunostaining a fixed sample or by expressing exogenous fluorescently...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2017) 130 (14): 2243–2250.
Published: 15 July 2017
... role of cell adhesion receptors in this process is established, it has only recently been appreciated that mechanical cues reach far beyond the plasma membrane and the cytoskeleton, and are directly transmitted to the nucleus. Furthermore, changes in the mechanical properties of the perinuclear...
Journal Articles
J Cell Sci (2017) 130 (12): 2066–2077.
Published: 15 June 2017
... the cytoplasm in 405 and 555 nm channels. This was performed to select the nucleus of interest and to standardize a normalization step. Nuclei as seen in the 405 and 555 nm channels (stained for DAPI and Nup62) had a border drawn on manually (Polygon selection tool), and the area outside the nuclei was cleared...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (18): 3412–3425.
Published: 15 September 2016
...Leonid A. Serebryannyy; Megan Parilla; Paolo Annibale; Christina M. Cruz; Kyle Laster; Enrico Gratton; Dmitri Kudryashov; Steven T. Kosak; Cara J. Gottardi; Primal de Lanerolle ABSTRACT Actin is abundant in the nucleus and it is clear that nuclear actin has important functions. However, mystery...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (10): 1981–1988.
Published: 15 May 2016
... regulate the nuclear localization of paxillin, suggesting a possible role for transcriptional control, through paxillin, by focal adhesions. Paxillin is a LIM domain scaffold protein that localizes at focal adhesions and also cycles through the nucleus ( Brown and Turner, 2004 ). In prostate cancer cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (6): 1115–1127.
Published: 15 March 2016
... proteins to the NPC or nucleus, we performed quantitative immunofluorescence. Although supplementing X. laevis egg extract nuclei with additional NTF2 increased nuclear Ran levels, there were no significant changes in the amounts of nuclear RanGAP1, RCC1, RanBP1, RanBP2, CAS (also known as CSE1L), TRN...
Journal Articles
J Cell Sci (2016) 129 (2): 314–328.
Published: 15 January 2016
... species induce dephosphorylation of pTyr23AnxA2 located in the PML bodies of the nucleus, whereas AnxA2 associated with F-actin at the cell cortex is Tyr23 phosphorylated. The H 2 O 2 -induced responses in both compartments are transient and the pTyr23AnxA2 accumulating at the cell cortex is subsequently...
Journal Articles
J Cell Sci (2015) 128 (24): 4475–4486.
Published: 15 December 2015
...Filipe V. Almeida; Gernot Walko; James R. McMillan; John A. McGrath; Gerhard Wiche; Asa H. Barber; John T. Connelly ABSTRACT The transmission of mechanical forces to the nucleus is important for intracellular positioning, mitosis and cell motility, yet the contribution of specific components...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (19): 3607–3620.
Published: 1 October 2015
... Dechat , T. , Pfleghaar , K. , Sengupta , K. , Shimi , T. , Shumaker , D. K. , Solimando , L. and Goldman , R. D. ( 2008 ). Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin . Genes Dev.   22 , 832 - 853 . 10.1101/gad...
Includes: Supplementary data