...Joanna Kalita; Larisa E. Kapinos; Roderick Y. H. Lim ABSTRACT Macromolecular cargoes are asymmetrically partitioned in the nucleus or cytoplasm by nucleocytoplasmic transport (NCT). At the center of this activity lies the nuclear pore complex (NPC), through which soluble factors circulate...

...Suncica Barbato; Larisa E. Kapinos; Chantal Rencurel; Roderick Y. H. Lim ABSTRACT Ran is a small GTPase whose nucleotide-bound forms cycle through nuclear pore complexes (NPCs) to direct nucleocytoplasmic transport (NCT). Generally, Ran guanosine triphosphate (RanGTP) binds cargo-carrying...

... Nuclear pore Nucleocytoplasmic transport Oxidative stress Disulfide (S–S) bond formation within and between proteins plays an important role in protein folding, stability, function, and protein–protein interaction. Reactive oxygen species (ROS) directly or indirectly oxidize the thiol group...

... ( m.w.goldberg@durham.ac.uk ) 5 5 2010 © 2010. 2010 Nucleocytoplasmic transport Nuclear pore complex mRNA export Protein import Transmission electron microscopy Nuclear pore complexes (NPCs) are the sole gates for regulated exchange of macromolecules between the nucleus...

... synthesis is dispensable in wild-type cells, viability of brr6-1 cells was fully dependent on neutral lipid production. These data indicate that Brr6 has an essential function in regulating lipid homeostasis in the NE-ER, thereby impacting NPC formation and nucleocytoplasmic transport. Fig. 6...

...Dmitry Yudin; Mike Fainzilber The GTPase Ran is best known for its crucial roles in the regulation of nucleocytoplasmic transport in interphase cells and in the organization of the spindle apparatus during mitosis. A flurry of recent reports has now implicated Ran in diverse cytoplasmic events...

... Actin Nucleocytoplasmic transport Cajal bodies Nuclear matrix Nuclear pore complex Nucleolus Protein 4.1 Nuclear pore complexes (NPCs) are embedded in the nuclear envelope, where they mediate and regulate nucleocytoplasmic transport (reviewed by Fahrenkrog and Aebi, 2003 ; Vasu...

...Martijn J. van Hemert; Maarten Niemantsverdriet; Thomas Schmidt; Claude Backendorf; Herman P. Spaink Nucleocytoplasmic transport of proteins plays an important role in the regulation of many cellular processes. Differences in nucleocytoplasmic shuttling can provide a basis for isoform-specific...

...Francisco J. Nicolás; William J. Moore; Chuanmao Zhang; Paul R. Clarke Ran is a multifunctional small GTPase of the Ras superfamily that plays roles in nucleocytoplasmic transport, mitotic spindle assembly and nuclear envelope formation. By screening a Xenopus oocyte cDNA library for Ran-GTP...