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Keywords: Nuclear transport
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Journal Articles
J Cell Sci (2021) 134 (2): jcs247874.
Published: 25 January 2021
... and it regulates nucleocytoplasmic transport, which is key to processes including transcriptional regulation and cell cycle control. Accordingly, components of the nuclear transport machinery are often found to be dysregulated or hijacked in diseases. In this Cell Science at a Glance article and accompanying...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (6): jcs237156.
Published: 26 March 2020
... ). As these varied functions of Nups would imply, the consequences of loss-of-function mutations of a given Nup on gene expression are a product of both direct effects on chromatin structure and indirect effects arising from alteration of the nuclear transport pathway discussed above. Thus, it is important...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (7): jcs225698.
Published: 8 April 2019
... Nuclear transport Human tissues are exposed to reduced oxygen concentration (hypoxia) during physiological processes like development and differentiation, but also in pathological situations like ischemia, inflammation and cancer ( Semenza, 2011 ). In order to adapt to the hypoxic environment...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (1): jcs206326.
Published: 4 January 2018
...Masahiro Kumeta; Hide A. Konishi; Wanzhen Zhang; Sayuri Sakagami; Shige H. Yoshimura ABSTRACT The karyopherin family of nuclear transport receptors is composed of a long array of amphiphilic α-helices and undergoes flexible conformational changes to pass through the hydrophobic crowding barrier...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (24): 4439–4447.
Published: 15 December 2016
.... Annulate lamellae Nuclear envelope Nuclear pore complex Nuclear transport Envelopment of the genetic material by the nuclear envelope is a hallmark of eukaryotic cells. By spatially and temporally separating nuclear transcription and RNA processing, as well as cytosolic translation, the nuclear...
Journal Articles
J Cell Sci (2016) 129 (6): 1115–1127.
Published: 15 March 2016
... by ectopic NTF2 expression. These data suggest that NTF2 may be a novel cancer biomarker, and it will be important to examine if this trend holds true for other cancer types. Interestingly, another nuclear transport factor, importin α2, has been implicated as a biomarker for breast and non-small cell lung...
Journal Articles
J Cell Sci (2014) 127 (8): 1647–1659.
Published: 15 April 2014
... with a dense insoluble fraction. We finally examine the impact of full-length and truncated APC on β-catenin nuclear transport. We observe that β-catenin is transported much faster than previously thought. Although this fast translocation is largely insensitive to the presence of wild-type or truncated APC...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (21): 4979–4984.
Published: 1 November 2012
... proteins without nuclear localization signals are localized to the nucleus. In this paper, we provide evidence for the spontaneous migration of large proteins in a karyopherin-independent manner. Time-lapse observation of a nuclear transport assay revealed that several large molecules spontaneously...
Journal Articles
J Cell Sci (2007) 120 (19): 3436–3445.
Published: 1 October 2007
... cycle? Trends Cell Biol. 11 , 366 -371. Cushman, I., Stenoien, D. and Moore, M. S. ( 2004 ). The dynamic association of RCC1 with chromatin is modulated by Ran-dependent nuclear transport. Mol. Biol. Cell 15 , 245 -255. Dasso, M. ( 2002 ). The Ran GTPase: theme and variations. Curr...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (23): 4952–4963.
Published: 1 December 2006
... 2006 © The Company of Biologists Limited 2006 2006 Phosphorylation Signal transduction Nuclear transport Kinase Phosphatase MAP kinase The extracellular signal-regulated protein kinase ERK1/2 [P42/P44 mitogen-activated protein kinase (MAPK)] is one of the main transducers...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (21): 4409–4419.
Published: 1 November 2006
... NFκB signaling Nuclear transport Nuclear pore complexes (NPCs) are protein channels spanning the nuclear envelope to conduct macromolecular transport between the nucleus and the cytoplasm (reviewed by Suntharalingam and Wente, 2003 ). Genetic and biochemical studies in yeast and mammalian...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (1): 233–242.
Published: 1 January 2005
.... Henderson, B. R. and Fagotto, F. ( 2002 ). The ins and outs of APC and beta-catenin nuclear transport. EMBO Rep. 3 , 834 -839. Herold, A., Suyama, M., Rodrigues, J. P., Braun, I. C., Kutay, U., Carmo-Fonseca, M., Bork, P. and Izaurralde, E. ( 2000 ). TAP (NXF1) belongs to a multigene family...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2003) 116 (21): 4401–4408.
Published: 1 November 2003
... 2003 2003 HIV-1 Integrase Nuclear transport Preintegration complex In contrast to simpler retroviruses, lentiviruses such as human immunodeficiency virus type 1 (HIV-1) have evolved the unique ability to infect nondividing cells. Thus, the HIV preintegration complex (PIC) probably...
Journal Articles
J Cell Sci (2002) 115 (14): 2997–3005.
Published: 15 July 2002
...Carl Feldherr; Debra Akin; Trevor Littlewood; Murray Stewart In this report we investigated the activity of vertebrate nuclear transport factors in a primitive organism, Amoeba proteus , to better understand evolutionary changes in the transport mechanisms of organisms expected to have different...
Journal Articles
J Cell Sci (2001) 114 (24): 4621–4627.
Published: 15 December 2001
... that increases in functional pore size are related to a reduction in the amount of available p53. To further test this hypothesis, we investigated the effects of cycloheximide and pifithrin-α, which inhibits p53-dependent transcriptional activation, on nuclear transport. After 3 hours in cycloheximide...
Journal Articles
J Cell Sci (2001) 114 (19): 3479–3485.
Published: 1 October 2001
... family of transport receptors, and the findings add additional evidence for nuclear assembly of SRP. ‡Author for correspondence (e-mail: refried@email.unc.edu ) 18 6 2001 © The Company of Biologists Limited 2001 2001 Importin Nuclear transport Nucleolus Signal recognition...
Journal Articles
J Cell Sci (2001) 114 (14): 2641–2648.
Published: 15 July 2001
... is found bound to ribosomes via Egd1p or Btt1p (J.F. et al., unpublished; Reimann et al., 1999 ). NAC Nuclear transport Saccharomyces cerevisiae © The Company of Biologists Limited 2001 2001 6 4 2001 References Adam, S. A., Sterne Marr, R. and Gerace, L. ( 1990...
Journal Articles
J Cell Sci (1989) 1989 (Supplement_11): 225–242.
Published: 1 January 1989
... developed an in vitro transport system and have begun to dissect the highly selective process of nuclear transport. The basic parameters of transport were defined using an easily isolated nuclear protein, nucleoplasmin. To study the interaction of nuclear targeting signals with the pore, an artificial...