... and it regulates nucleocytoplasmic transport, which is key to processes including transcriptional regulation and cell cycle control. Accordingly, components of the nuclear transport machinery are often found to be dysregulated or hijacked in diseases. In this Cell Science at a Glance article and accompanying...

... alterations in passive diffusion can modulate gene expression. Nuclear pore complex Nup170 SAGA complex SLIK complex Nuclear transport Passive diffusion Yeast Canadian Institutes of Health Research 10.13039/501100000024 MOP 106502 The nuclear envelope (NE) double membrane...

... Nuclear transport State Scholarships Foundation 10.13039/501100003447 Human tissues are exposed to reduced oxygen concentration (hypoxia) during physiological processes like development and differentiation, but also in pathological situations like ischemia, inflammation and cancer...

...Masahiro Kumeta; Hide A. Konishi; Wanzhen Zhang; Sayuri Sakagami; Shige H. Yoshimura ABSTRACT The karyopherin family of nuclear transport receptors is composed of a long array of amphiphilic α-helices and undergoes flexible conformational changes to pass through the hydrophobic crowding barrier...

.... Annulate lamellae Nuclear envelope Nuclear pore complex Nuclear transport European Research Council 10.13039/501100000781 309528 CHROMDECON Deutsche Forschungsgemeinschaft 10.13039/501100001659 DFG AN 377/6-1 Envelopment of the genetic material by the nuclear envelope...

... 2016 © 2016. Published by The Company of Biologists Ltd 2016 Summary: NTF2 reduces the diameter of the NPC, nuclear import of large cargos and nuclear size in a Ran-binding-dependent manner, in both Xenopus and mammalian cells. Nucleus NTF2 Nuclear transport Ran Nuclear pore...

... with a dense insoluble fraction. We finally examine the impact of full-length and truncated APC on β-catenin nuclear transport. We observe that β-catenin is transported much faster than previously thought. Although this fast translocation is largely insensitive to the presence of wild-type or truncated APC...

... proteins without nuclear localization signals are localized to the nucleus. In this paper, we provide evidence for the spontaneous migration of large proteins in a karyopherin-independent manner. Time-lapse observation of a nuclear transport assay revealed that several large molecules spontaneously...

... by Ran-dependent nuclear transport. Mol. Biol. Cell 15 , 245 -255. Dasso, M. ( 2002 ). The Ran GTPase: theme and variations. Curr. Biol. 12 , R502 -R508. Fornerod, M., Ohno, M., Yoshida, M. and Mattaj, I. W. ( 1997 ). CRM1 is an export receptor for leucine-rich nuclear export signals...

... are dynamically regulated in living cells. * Author for correspondence (e-mail: [email protected] ) 20 9 2006 © The Company of Biologists Limited 2006 2006 Phosphorylation Signal transduction Nuclear transport Kinase Phosphatase MAP kinase The extracellular signal-regulated...

... responses. ‡ Author for correspondence (e-mail: [email protected] ) * These authors contributed equally to this work 4 8 2006 © The Company of Biologists Limited 2006 2006 Drosophila Nucleoporins Nup214 CRM1 export NFκB signaling Nuclear transport Nuclear...

... The Company of Biologists Limited 2005 2005 Ataxin-1 Spinocerebellar ataxia type 1 RNA processing Nuclear transport Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant, progressive neurodegenerative disease. Primary sites of neurodegeneration in the brain are the Purkinje cells...

... of Biologists Limited 2003 2003 HIV-1 Integrase Nuclear transport Preintegration complex In contrast to simpler retroviruses, lentiviruses such as human immunodeficiency virus type 1 (HIV-1) have evolved the unique ability to infect nondividing cells. Thus, the HIV preintegration complex (PIC...

...Carl Feldherr; Debra Akin; Trevor Littlewood; Murray Stewart In this report we investigated the activity of vertebrate nuclear transport factors in a primitive organism, Amoeba proteus , to better understand evolutionary changes in the transport mechanisms of organisms expected to have different...

... that increases in functional pore size are related to a reduction in the amount of available p53. To further test this hypothesis, we investigated the effects of cycloheximide and pifithrin-α, which inhibits p53-dependent transcriptional activation, on nuclear transport. After 3 hours in cycloheximide...

... family of transport receptors, and the findings add additional evidence for nuclear assembly of SRP. ‡Author for correspondence (e-mail: [email protected] ) 18 6 2001 © The Company of Biologists Limited 2001 2001 Importin Nuclear transport Nucleolus Signal recognition...

... Limited 2001 2001 NAC Nuclear transport Saccharomyces cerevisiae The nascent polypeptide-associated complex (NAC) is an evolutionarily conserved protein complex. Three NAC subunits are present in yeast: Egd2p, Btt1p and Egd1p. Egd2p is homologous to αNAC proteins in mammals (Shi et al...

... contributes to its concentration in the nucleus. * Author for correspondence (e-mail: [email protected] ) 27 01 2001 © 2001 by Company of Biologists 2001 hnRNP protein Nuclear transport Transcription Mouse embryo The heterogeneous nuclear RNA-binding proteins (hnRNP...

... Nuclear transport Chromosome decondensation Eukaryotic chromosomes are spatially organized within the nucleus, the boundary of which is formed by the nuclear envelope. The envelope consists of a double membrane, nuclear pore complexes (NPCs), and the nuclear lamina (for reviews see Marshall...

... labelling Nuclear pore Nuclear transport The nuclear pore acts as a gate in the nuclear envelope that permits exchange of macromolecules between nucleus and cytoplasm (reviewed by Akey, 1995 ; Bastos et al., 1995 ; Davis, 1995; Panté and Aebi, 1996 ; Mattaj and Englmeier, 1998 ; Yang et al...