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Keywords: Nuclear translocation
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Journal Articles
J Cell Sci (2021) 134 (17): jcs258456.
Published: 03 September 2021
... is ubiquitously expressed with elevated expression in certain contexts. We detected cytosol-to-nuclear translocation of MPK-1 in maturing oocytes and hence validated nuclear translocation as a reporter of some activation events. During patterning of vulval precursor cells (VPCs), MPK-1 is necessary and sufficient...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (15): jcs252981.
Published: 03 August 2021
... of Biologists Ltd 2021 Summary: This Review expands our knowledge and contributes to research focusing on the role of TFEB in host-pathogen relationships and the feasibility of TFEB as a drug target. Autophagy Lysosome Inflammatory TFEB Nuclear translocation Infection Innate immunity...
Journal Articles
J Cell Sci (2021) 134 (8): jcs255273.
Published: 22 April 2021
... Glyceraldehyde-3-phosphate dehydrogenase, GAPDH Nuclear translocation Reductase activity Colorectal cancer is one of the leading causes of cancer death worldwide ( Puccini and Lenz, 2018 ; Hubbard and Grothey, 2015 ; Siegel et al., 2014 ; Schmoll and Stein, 2014 ). The incidence of the disease...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (18): jcs229534.
Published: 26 September 2019
... that the p38 dissociated from mutant K8 makes a complex with Hsp70, which is known as a potential chaperone for p38 nuclear translocation. Comparison of p38 MAPK binding with keratin variants associated with liver disease showed that the K18 I150V variant dramatically reduced binding with p38, which is similar...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (22): jcs219782.
Published: 19 November 2018
... of HIF. 2-Oxoglutarate 2-OG Dioxygenase inhibitors FIH Factor inhibiting HIF HIF asparaginyl hydroxylase Hypoxia Nuclear translocation Summary: Nuclear localization of FIH is governed by two opposing processes: nuclear entry by ‘coupling’ with HIF1α for importin β1-mediated nuclear...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (15): 2481–2490.
Published: 01 August 2017
... without detectable EGFR nuclear translocation. Hence, DNA damage alone is not sufficient to induce EGFR endocytosis. EGF receptor p38 MAPK Endocytosis Nuclear translocation The ligand-stimulated endocytosis of EGF receptor (EGFR) and endosomal sorting complexes required for transport...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (3): 487–498.
Published: 01 February 2015
... formation, which correlated with reduced Smad2 nuclear translocation. Interestingly, we also detected an increase in p38 MAPK phosphorylation and apoptosis in aPKC-silenced cells, which were found to be TRAF6-dependent. Taken together, our results suggest that aPKC isoforms regulate Smad and non-Smad TGFβ...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (11): 2480–2492.
Published: 01 June 2013
... that phosphorylation of the APP intracellular domain (AICD) at T668 is necessary for its interaction with FE65 in the nucleus ( Chang et al., 2006 ), that phosphorylation of T668 leads to FE65 nuclear translocation ( Nakaya et al., 2008 ), and that pT668 APP is elevated in AD brain ( Shin et al., 2007 ) suggest a role...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (2): 625–637.
Published: 15 January 2013
...@faculty.chiba-u.jp ) 13 11 2012 © 2013. Published by The Company of Biologists Ltd 2013 ErbB4 Nuclear translocation EGFR Src-family tyrosine kinases Histone modification Protein-tyrosine kinases are found in multicellular organisms and have important roles in a variety...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (14): 3421–3429.
Published: 15 July 2012
... Nuclear translocation Kinase activity Neuron Cdk5 is a member of the cyclin-dependent kinase (Cdk) family that is activated by the regulatory subunits p35 and p39. In contrast to the cell cycle-related Cdks in proliferating cells, Cdk5 plays a role in various activities unrelated to cell-cycle...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (10): 1716–1723.
Published: 15 May 2010
... regulatory mechanism of EGFR nuclear function and could have important implications for evaluating nuclear localization in cancer. * Author for correspondence ( jschroeder@azcc.arizona.edu ) 6 3 2010 © 2010. 2010 MUC1 EGFR Cyclin D1 Nuclear translocation Breast cancer...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (8): 1604–1611.
Published: 15 April 2006
.... Following Ca 2+ -calmodulin stimulation, calcineurin dephosphorylates NFAT proteins and induces their translocation into the nucleus. However, NFAT nuclear translocation has never been investigated in skeletal muscle in vivo. To determine whether NFATc1 nucleocytoplasmic shuttling depends on muscle activity...
Journal Articles
J Cell Sci (2002) 115 (10): 2165–2177.
Published: 15 May 2002
... uptake of ferritin was re-established ( Fig. 5E ). These experiments indicated that the uptake of ferritin was active and occurred via the nuclear pore. However, those experiments did not address whether cytosolic factors were required for ferritin nuclear translocation. Consequently, cell cultures...
Journal Articles
J Cell Sci (2001) 114 (12): 2327–2334.
Published: 15 June 2001
...-specific nuclear translocation, cultured corneal epithelial cells and corneal fibroblasts were transfected with a series of deletion constructs for the heavy chain of ferritin, ferritin-H, tagged with a human c-myc epitope. The subcellular localization of the ferritin was determined by immunofluorescence...
Journal Articles
J Cell Sci (1993) 104 (4): 949–955.
Published: 01 April 1993
... nuclear translocation REFERENCES Adams S. R. , Harootunian A. T. , Buechler Y. J. , Taylor S. S. , Tsien R. Y. ( 1991 ). Fluorescence ratio imaging of cyclic AMP in single cells. Nature 349 , 694 – 697 Baeuerle P. A. , Baltimore D. ( 1988...