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Keywords: Nuclear translocation
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Journal Articles
J Cell Sci (2021) 134 (17): jcs258456.
Published: 3 September 2021
... is ubiquitously expressed with elevated expression in certain contexts. We detected cytosol-to-nuclear translocation of MPK-1 in maturing oocytes and hence validated nuclear translocation as a reporter of some activation events. During patterning of vulval precursor cells (VPCs), MPK-1 is necessary and sufficient...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (15): jcs252981.
Published: 3 August 2021
... reduces MARCO expression, demonstrating a link between TFEB nuclear translocation and MARCO expression ( Wu et al., 2017 ). However, the above study is inconsistent with other reports where IFN-γ stimulation of macrophages leads to nuclear translocation of TFEB ( Taylor et al., 2014 ; Singh et al., 2018...
Journal Articles
J Cell Sci (2021) 134 (8): jcs255273.
Published: 22 April 2021
... starvation Glyceraldehyde-3-phosphate dehydrogenase, GAPDH Nuclear translocation Reductase activity Colorectal cancer is one of the leading causes of cancer death worldwide ( Puccini and Lenz, 2018 ; Hubbard and Grothey, 2015 ; Siegel et al., 2014 ; Schmoll and Stein, 2014 ). The incidence...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (18): jcs229534.
Published: 26 September 2019
... that the p38 dissociated from mutant K8 makes a complex with Hsp70, which is known as a potential chaperone for p38 nuclear translocation. Comparison of p38 MAPK binding with keratin variants associated with liver disease showed that the K18 I150V variant dramatically reduced binding with p38, which is similar...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (22): jcs219782.
Published: 19 November 2018
... exportin 1 (CRM1)-dependent pathway. 2-Oxoglutarate 2-OG Dioxygenase inhibitors FIH Factor inhibiting HIF HIF asparaginyl hydroxylase Hypoxia Nuclear translocation FIH was initially isolated as a negatively regulating factor of HIFα following a yeast two-hybrid screen using...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (15): 2481–2490.
Published: 1 August 2017
... on endocytosis or nuclear import. Nuclear accumulation could facilitate interaction with DNA-PK. However, the presence of a cytoplasmic pool of DNA-PK potentially renders this substrate of the EGFR kinase accessible without EGFR endocytosis and nuclear translocation. Alternatively, very low levels of EGFR...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (3): 487–498.
Published: 1 February 2015
... formation, which correlated with reduced Smad2 nuclear translocation. Interestingly, we also detected an increase in p38 MAPK phosphorylation and apoptosis in aPKC-silenced cells, which were found to be TRAF6-dependent. Taken together, our results suggest that aPKC isoforms regulate Smad and non-Smad TGFβ...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (11): 2480–2492.
Published: 1 June 2013
... regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration.   Mol. Cell. Biol.   26 , 4327 – 4338 . 10.1128/MCB.02393-05 Coppedè   F. , Migliore   L. ( 2010 ). Evidence linking genetics, environment, and epigenetics to impaired DNA repair...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (2): 625–637.
Published: 15 January 2013
... tyrosine phosphorylation ( Dittmann et al., 2008 ; Iida et al., 2013 ). * Author for correspondence ( nyama@faculty.chiba-u.jp ) 13 11 2012 © 2013. Published by The Company of Biologists Ltd 2013 ErbB4 Nuclear translocation EGFR Src-family tyrosine kinases Histone...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (14): 3421–3429.
Published: 15 July 2012
... for correspondence ( a7203ki@tmu.ac.jp ) 7 2 2012 © 2012. Published by The Company of Biologists Ltd 2012 Cdk5 Subcellular localization Membrane association Nuclear translocation Kinase activity Neuron Cdk5 is a member of the cyclin-dependent kinase (Cdk) family that is activated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (10): 1716–1723.
Published: 15 May 2010
.... B. ( 1999 ). VEGF induces nuclear translocation of Flk-1/KDR, endothelial nitric oxide synthase, and caveolin-1 in vascular endothelial cells . Biochem. Biophys. Res. Commun. 256 , 192 - 197 . Gillett C. , Fantl V. , Smith R. , Fisher C. , Bartek J. , Dickson...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (8): 1604–1611.
Published: 15 April 2006
.... Following Ca 2+ -calmodulin stimulation, calcineurin dephosphorylates NFAT proteins and induces their translocation into the nucleus. However, NFAT nuclear translocation has never been investigated in skeletal muscle in vivo. To determine whether NFATc1 nucleocytoplasmic shuttling depends on muscle activity...
Journal Articles
J Cell Sci (2002) 115 (10): 2165–2177.
Published: 15 May 2002
... translocation of NLS-containing proteins, did not affect ferritin nuclear translocation. Thus, the entry of ferritin into the nucleus is not dependent upon NLS-containing proteins( Duverger et al., 1995 ). This latter observation is also consistent with sequence data for ferritin( Boyd et al., 1985...
Journal Articles
J Cell Sci (2001) 114 (12): 2327–2334.
Published: 15 June 2001
...-specific nuclear translocation, cultured corneal epithelial cells and corneal fibroblasts were transfected with a series of deletion constructs for the heavy chain of ferritin, ferritin-H, tagged with a human c-myc epitope. The subcellular localization of the ferritin was determined by immunofluorescence...
Journal Articles
J Cell Sci (1993) 104 (4): 949–955.
Published: 1 April 1993
... nuclear translocation REFERENCES Adams S. R. , Harootunian A. T. , Buechler Y. J. , Taylor S. S. , Tsien R. Y. ( 1991 ). Fluorescence ratio imaging of cyclic AMP in single cells. Nature 349 , 694 – 697 Baeuerle P. A. , Baltimore D. ( 1988...