...Takashi Okabe; Rohit Chavan; Sara S. Fonseca Costa; Andrea Brenna; Jürgen A. Ripperger; Urs Albrecht ABSTRACT REV-ERBα (encoded by Nr1d1 ) is a nuclear receptor that is part of the circadian clock mechanism and regulates metabolism and inflammatory processes. The glucocorticoid receptor (GR...

... 2014 Retinoic acid RA RAR Nuclear receptor Phosphorylation Transcription Differentiation Retinoic acid (RA), the active metabolite of vitamin A, regulates multiple biological processes and plays key roles in embryonic development through the regulation of cell growth...

... ) 29 04 2013 © 2013. Published by The Company of Biologists Ltd 2013 Nuclear receptor Glucocorticoid GR Heat shock protein 90 Crystal structure Subcellular trafficking Synthetic glucocorticoids are potent anti-inflammatory drugs used to treat multiple conditions including...

... cells. * These authors contributed equally to this work ‡ Author for correspondence ( [email protected] ) 3 12 2012 © 2013. Published by The Company of Biologists Ltd 2013 Meis1 Differentiation Transcription Nuclear receptor Retinoic acid receptor Epigenetics...

...Peter Brazda; Tibor Szekeres; Balázs Bravics; Katalin Tóth; György Vámosi; Laszlo Nagy The retinoic acid receptor (RAR) is a member of the nuclear receptor superfamily. This ligand-inducible transcription factor binds to DNA as a heterodimer with the retinoid X receptor (RXR) in the nucleus...

... high throughput microscopy approach. In support of the nuclear receptor hit-and-run model, photobleaching studies provided direct evidence of very transient ER-array interactions, and revealed ligand-dependent changes in k off . ERα-truncation mutants indicated that helix-12 and interactions with co...

... asymmetric division that separates them. The seam cell contacts are important for epidermal differentiation, but what regulates the cell-shape changes that restore them is unknown. Here, we show that NHR-25, a transcription factor of the nuclear receptor family, is expressed in the seam cells...

... concentration. In view of the fact that retinoic acid is a naturally occurring metabolite of vitamin A, this raises the possibility that it is deployed in vivo as an endogenous morphogen. Furthermore, the recent evidence that its effects are mediated by nuclear receptors of the steroid/thyroid hormone...