..., to deliver their mechanosensory functions. Desmosomes Intermediate filaments Mechanosensory function Plasma membrane Nuclear lamins LINC Deutsche Forschungsgemeinschaft 10.13039/501100001659 LE 566/18-2 LE 566/20-1 and LE 566/22-1;REL Fight for Sight UK 10.13039...

... ) 5 5 2010 © 2010. 2010 Cellular senescence DNA damage Nuclear lamins Telomerase Telomere dysfunction Tumor suppressors Hutchinson-Gilford progeria syndrome (HGPS) is a premature-aging syndrome which affects one in 4-8 million children with symptoms resembling normal adult...

... to this level of organization is largely unresolved. To test the links between structure and function, we evaluated how nuclear lamins contribute to the organization of a major functional compartment, the nucleolus. HeLa cells with compromised expression of the genes encoding lamins were analyzed using high...

...Manfred Alsheimer; Bodo Liebe; Lori Sewell; Colin L. Stewart; Harry Scherthan; Ricardo Benavente Nuclear lamins are structural protein components of the nuclear envelope. Mutations in LMNA , the gene coding for A-type lamins, result in several human hereditary diseases, the laminopathies, which...

... the characterization of the mammalian nuclear lamins. While lamins A/C appear as nonessential proteins in the mouse embryo and in RNAi treated cultured cells, the two other lamins, B1 and B2, are now identified as essential proteins. Interestingly the inner nuclear membrane protein emerin, thought to be a ligand...

... hours post treatment was characterized by degradation of other nucleolar and nuclear proteins such as nuclear lamins, topoisomerase I and B23. In conclusion, remarkable segregation of nucleolar argyrophilic proteins, nucleolar RNA and a simultaneous activation of the cascade of caspases markedly...

...Nancy Maus; Nico Stuurman; Paul A. Fisher ABSTRACT Stage 14 Drosophila oocytes are arrested in first meiotic metaphase. A cell-free extract of these oocytes catalyzes apparent disassembly of purified Drosophila nuclei as well as of nuclear lamin polymers formed in vitro from isolated interphase...

... the general utility of p3PK by redirecting CMPK to mitochondria (using the twelve amino acid pre-sequence of yeast cytochrome c oxidase subunit IV) and to the nucleus (using a putative eight amino acid nuclear localization signal from human nuclear lamins A and C). We also report that, contrary...

.... With the aid of a novel broad-reacting lamin antibody we have demonstrated the expression of a protein that is closely related, if not identical, to lamin B1. * Author for correspondence 26 08 1992 29 10 1992 © 1993 by Company of Biologists 1993 karyoskeleton nuclear lamins...

... assembly/disassembly and mitosis in plants may be similar to that in animal cells. * To whom correspondence should be addressed 06 04 1992 13 07 1992 © 1992 by Company of Biologists 1992 nuclear lamins intermediate filaments Pisum sativum (pea) The nuclear...

... nuclear lamins intermediate filaments somatic cells Lamins A and C were detected both by light microscopy and on blots using a murine monoclonal antibody (IgM) produced in suspension culture of the hybridoma cell line 41CC4 kindly provided by Dr G. Warren (University of Dundee, Dundee, Scotland...