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Keywords: Nuclear import
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Journal Articles
J Cell Sci (2021) 134 (7): jcs258391.
Published: 15 April 2021
... physically interacts with proteasome proteins, and Ipo9 mutant males exhibit disruption of the nuclear localization of several proteasome components. Thus, Ipo9 coordinates the nuclear import of functionally related factors necessary for the completion of gametogenesis. This article has an associated First...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (10): jcs225524.
Published: 15 May 2019
... within 20 min of reformation of the nucleus, after which import comes to an abrupt halt. This suggests that maintaining the nuclear–cytosol distribution after mitosis requires chromatin condensation to exclude cytosolic material from the nuclear space, and specialized machineries for nuclear import...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (21): 4025–4033.
Published: 01 November 2016
... for the broad range of cellular functions of the protein is incompletely understood. We show that HuR controls the expression of multiple components of the nuclear import machinery. Consequently, HuR is crucial for the nuclear import of cellular retinoic acid-binding protein 2 (CRABP2), which delivers RA...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (15): 2905–2911.
Published: 01 August 2016
... to this canonical nuclear import pathway. Here, we report a new unconventional nuclear import mechanism exploited by the baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV). We found that AcMNPV nucleocapsids entered the nucleus of digitonin-permeabilized cells in the absence of exogenous...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (22): 4151–4159.
Published: 15 November 2015
... formation of FUS in ALS and FTLD. Here, we show that the C-terminal tyrosine residue at position 526 of FUS is crucial for normal nuclear import. This tyrosine is subjected to phosphorylation, which reduces interaction with transportin 1 and might consequentially affect the transport of FUS into the nucleus...
Journal Articles
J Cell Sci (2013) 126 (15): 3333–3343.
Published: 01 August 2013
... leukemias and solid tumor formation. As a regulated transcription factor, precise cellular localization of STAT5 is essential. Conventional nuclear localization signals consist of short stretches of basic amino acids. In this study, we provide evidence that STAT5 nuclear import is dependent...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (8): 1100–1110.
Published: 15 April 2009
... factor for transportin-mediated nuclear import. Depletion of Nup358 resulted in a strong inhibition of nuclear import of the human immunodeficiency virus type 1 (HIV-1) Rev protein. HIV-1 Rev is an RNA-binding protein that is required for CRM1 (also known as exportin 1)-dependent nuclear export...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (7): 957–968.
Published: 01 April 2008
...Mark L. Cutress; Hayley C. Whitaker; Ian G. Mills; Murray Stewart; David E. Neal Ligand-dependent nuclear import is crucial for the function of the androgen receptor (AR) in both health and disease. The unliganded AR is retained in the cytoplasm but, on binding 5α-dihydrotestosterone...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (1): 23–30.
Published: 01 January 2006
... of this genome as a densely packaged, rodlike structure. * Author for correspondence (e-mail: vs297@cam.ac.uk ) 21 9 2005 © The Company of Biologists Limited 2006 2006 Atomic force microscopy Herpes simplex virus type-1 Viral genome Nuclear import Nuclear pore complex...
Journal Articles
J Cell Sci (2005) 118 (23): 5453–5463.
Published: 01 December 2005
... nuclear import is transcription-dependent. We identified RRM2 and the first half of the auxiliary region as important determinants for TIAR and TIA-1 nuclear accumulation. In contrast, the nuclear export of TIAR and TIA-1 is mediated by RRM3. Both RRMs contribute to TIAR and TIA-1 nuclear accumulation...
Journal Articles
J Cell Sci (2005) 118 (7): 1355–1362.
Published: 01 April 2005
... never been described for a transcription factor and could explain the inhibitory activity of HBZ. * Author for correspondence (e-mail: jean-michel.mesnard@univ-montp1.fr ) 13 1 2005 © The Company of Biologists Limited 2005 2005 HTLV-I HBZ bZIP protein Nuclear import...
Journal Articles
J Cell Sci (2004) 117 (25): 6143–6152.
Published: 01 December 2004
...-receptor-clustering gene rapsyn . Similar to other BTB/POZ proteins (e.g. Bcl-6, PLZF, HIC-1), endogenous Kaiso localizes predominantly to the nuclei of mammalian cells. To date, however, the mechanism of nuclear import for most POZ transcription factors, including Kaiso, remain unknown. Here, we report...
Journal Articles
J Cell Sci (2004) 117 (22): 5283–5292.
Published: 15 October 2004
... sequence-tagged CapG-EGFP fails to induce invasion, whereas point mutations in the nuclear export sequence permitting nuclear re-entry restore cellular invasion. Nuclear import of CapG is energy-dependent and requires the cytosolic receptor importin β but not importin α. Nuclear CapG does not possess...
Journal Articles
J Cell Sci (2004) 117 (18): 4113–4125.
Published: 15 August 2004
... of Gent, K.L. Ledeganckstraat 35, 9000 Gent, Belgium 22 4 2004 © The Company of Biologists Limited 2004 2004 TGF-β Smad Nucleocytoplasmic shuttling GFP Nuclear import Nuclear export Photobleaching Signals from receptors for Transforming growth factor β (TGF-β...
Journal Articles
J Cell Sci (2004) 117 (13): 2675–2686.
Published: 01 June 2004
... of a nuclear localization signal by the nuclear import factor karyopherin α. Cell 94 , 193 -204. Crawford, H. C., Fingleton, B. M., Rudolph-Owen, L. A., Goss, K. J. H., Rubinfeld, B., Polakis, P. and Matrisian, L. M. ( 1999 ). The metalloproteinase matrilysin is a target of β-catenin transactivation...
Journal Articles
J Cell Sci (2004) 117 (9): 1857–1866.
Published: 01 April 2004
... within the putative nuclear localization signal, T445, is required for efficient nuclear import of a GST-carboxy-tail fusion, two others, S421 and S423, appear to effect release from the import receptors. Although overexpression of recombinant HDACm in oocytes leads to premature condensation...
Journal Articles
J Cell Sci (2003) 116 (19): 3949–3956.
Published: 01 October 2003
... of promiscuously A-to-I edited RNAs. Cell 106 , 465 -475. Our present results reveal that the Hrp65-Hrp65 interaction is required for the localization of the Hrp65 isoforms inside the cell. The nuclear import of Hrp65-1 is mediated by an NLS located in the C-terminus of the protein, whereas Hrp65-2...
Journal Articles
J Cell Sci (2002) 115 (19): 3739–3745.
Published: 01 October 2002
... for correspondence (e-mail: cal4a@virginia.edu ) 10 7 2002 © The Company of Biologists Limited 2002 2002 Nuclear import Green fluorescent protein Cell density Type 1 protein phosphatase (PP1) is an essential and highly conserved enzyme, with over 80% amino-acid sequence identity between...