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Keywords: Nuclear export and degradation
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Journal Articles

Antioxidant-induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2–Cul3–Rbx1 complex to allow normal Nrf2 activation and repression

James W. Kaspar, Suryakant K. Niture, Anil K. Jaiswal
Journal: Journal of Cell Science
J Cell Sci (2012) 125 (4): 1027–1038.
https://doi.org/10.1242/jcs.097295
Published: 15 February 2012
... or pre-induction response to antioxidants. Mutation of Tyr85 in INrf2 stymied the nuclear export of INrf2, suggesting that tyrosine phosphorylation controls the pre-induction nuclear export and degradation in response to antioxidants. The nuclear export of Cul3–Rbx1 were also blocked when INrf2Tyr85...
View article titled, Antioxidant-induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the <span class="search-highlight">nuclear</span> <span class="search-highlight">export</span> and <span class="search-highlight">degradation</span> of the INrf2–Cul3–Rbx1 complex to allow normal Nrf2 activation and repression
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