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Keywords: Nuclear export
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Journal Articles
J Cell Sci (2020) 133 (4): jcs239236.
Published: 24 February 2020
... the nucleo-cytoplasmic transport of USP16, and hence its function, is regulated has remained elusive. Here, we show that USP16 is predominantly cytoplasmic in all cell cycle phases. We identified the nuclear export signal (NES) responsible for maintaining USP16 in the cytoplasm. We found that USP16 is only...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (15): 3333–3343.
Published: 01 August 2013
... import is dependent on STAT5 nuclear import. STAT5 continually shuttles in and out of the nucleus and live cell imaging demonstrates that STAT5 nuclear export is mediated by both chromosome region maintenance 1 (Crm1)-dependent and Crm1-independent pathways. A Crm1-dependent nuclear export signal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (18): 4219–4229.
Published: 15 September 2012
.../APLP2 reveals that the proline-rich domain of Bat3 is required for its binding to YWK-II/APLP2. In addition, we find that the protein levels of YWK-II/APLP2 could be enhanced by nuclear export of Bat3 under apoptotic stimulation. We also find elevated levels of Bat3 and YWK-II/APLP2 in human colorectal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (17): 3977–3988.
Published: 01 September 2012
... through an active nuclear localization signal (NLS), accumulating in nuclear actin rods during stress. Here, we characterize the active nuclear export of cofilin through a leptomycin-B-sensitive, CRM1-dependent, nuclear export signal (NES). We also redefine the NLS of cofilin as a bipartite NLS...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2012) 125 (1): 144–154.
Published: 01 January 2012
... (exportin 1), the major export receptor, forms trimeric complexes with RanGTP and proteins containing nuclear export sequences (NESs). We analyzed the role of the nucleoporin-like protein 1, NLP1 (also known as hCG1 and NUPL2) in CRM1-dependent nuclear transport. NLP1, which contains many FG repeats...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (2): 192–201.
Published: 15 January 2010
.... ( 2007 ). Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma . Mol. Cell. Biol. 27 , 803 - 817 . Daynes R. A. , Jones D. C. ( 2002 ). Emerging roles of PPARs in inflammation and immunity . Nat. Rev. Immunol. 2 , 748...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (20): 3772–3779.
Published: 15 October 2009
... that cellular CRM1 became S-nitrosylated after extensive exposure to endogenous or exogenous nitric oxide (NO). This abrogated the interaction of CRM1 with nuclear export signals (NESs) and repressed classical protein export. Analysis by mass spectrometry and involving the use of S-nitrosylation mimetic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (8): 1111–1118.
Published: 15 April 2009
... to the cytoplasm. However, when the soluble pool of subunits is elevated by combined cold-nocodazole treatment and when constitutive nuclear export is inhibited by leptomycin B, tubulin accumulates in the cell nucleus. Transfection assays and FRAP experiments reveal that GFP-tagged β-tubulin shuttles between...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (17): 3695–3704.
Published: 01 September 2006
...-3-3 leads to the accumulation of nuclear p65-IκBα complexes and the constitutive association of p65 with the chromatin. In this situation, NFκB-dependent genes become unresponsive to TNFα stimulation. Together our results indicate that 14-3-3 proteins facilitate the nuclear export of IκBα-p65...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (23): 5453–5463.
Published: 01 December 2005
... nuclear import is transcription-dependent. We identified RRM2 and the first half of the auxiliary region as important determinants for TIAR and TIA-1 nuclear accumulation. In contrast, the nuclear export of TIAR and TIA-1 is mediated by RRM3. Both RRMs contribute to TIAR and TIA-1 nuclear accumulation...
Journal Articles
J Cell Sci (2004) 117 (23): 5579–5589.
Published: 01 November 2004
... export signal responsive to ROCK-activation. We conclude that a novel nuclear export is activated by the ROCK signaling pathway to exclude hnRNP C1/C2 from nucleus, by which the compartmentalization of specific hnRNP components is disturbed in apoptotic cells. * Author for correspondence (e-mail...
Journal Articles
J Cell Sci (2004) 117 (21): 4979–4990.
Published: 01 October 2004
... and accumulates until prophase, after which the protein disappears. We characterise a nuclear export sequence in the N-terminus of Cdc25B (amino acids 54-67) that, when mutated, greatly reduces the ability of Cdc25B to shuttle in a fluorescence loss in photobleaching assay. Mutation of the nuclear export sequence...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (18): 4113–4125.
Published: 15 August 2004
... of Gent, K.L. Ledeganckstraat 35, 9000 Gent, Belgium 22 4 2004 © The Company of Biologists Limited 2004 2004 TGF-β Smad Nucleocytoplasmic shuttling GFP Nuclear import Nuclear export Photobleaching Signals from receptors for Transforming growth factor β (TGF-β...
Journal Articles
J Cell Sci (2004) 117 (11): 2259–2270.
Published: 01 May 2004
... the study of mRNAs of certain early response genes (ERGs) containing the adenylate uridylate-rich element (ARE) in their 3′ untranslated regions (3′ UTRs). It was reported that HuR-mediated nuclear export of these mRNAs was CRM1-dependent under certain stress conditions. To further examine potential CRM1...
Journal Articles
J Cell Sci (2002) 115 (20): 3865–3871.
Published: 15 October 2002
.... and Rosbash, M. ( 2002 ). T7 RNA polymerase-directed transcripts are processed in yeast and link 3′ end formation to mRNA nuclear export. RNA 8 , 686 -697. Elliott, D. J. and Rosbash, M. ( 1996 ). Yeast pre-mRNA is composed of two populations with distinct kinetic properties. Exp. Cell Res. 229...
Journal Articles
J Cell Sci (2002) 115 (14): 2985–2995.
Published: 15 July 2002
... that efficient nuclear export of the small ribosomal subunit requires Yrb2, a factor involved in Crm1-mediated export. Furthermore, in cells lacking YRB2 , the stability and abundance of the small ribosomal subunit is decreased in comparison with the large ribosomal subunit. To identify additional factors...
Journal Articles
J Cell Sci (2002) 115 (2): 395–407.
Published: 15 January 2002
... to shuttle between nucleus and cytoplasm. Translocation of Xp54 from the nucleus to the cytoplasm appears to be dependent on the presence of a leucine-rich nuclear export signal (NES) and is blocked by leptomycin B, a specific inhibitor of the CRM1 receptor pathway. However, the C-terminal region of Xp54 can...