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Keywords: Nuclear envelope
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Journal Articles
J Cell Sci (2021) 134 (12): jcs258194.
Published: 21 June 2021
...Zeinab Jahed; Nya Domkam; Jessica Ornowski; Ghafar Yerima; Mohammad R. K. Mofrad ABSTRACT Large protein complexes assemble at the nuclear envelope to transmit mechanical signals between the cytoskeleton and nucleoskeleton. These protein complexes are known as the linkers of the nucleoskeleton...
Journal Articles
J Cell Sci (2020) 133 (20): jcs242172.
Published: 30 October 2020
... in interphase and becomes dumbbell shaped during mitotic division to facilitate the transfer of one nucleus to the daughter cell. Because yeast cells undergo closed mitosis, the nuclear envelope remains intact throughout the cell cycle. The pathways that regulate nuclear shape are not well characterized...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (16): jcs246546.
Published: 17 August 2020
... DNA, histones and various other nuclear proteins, including those enriched at the nuclear envelope, BAF appears to be essential for replicating cells to protect the genome and enable cell division. Cellular processes, such as innate immunity, post-mitotic nuclear reformation, repair of interphase...
Journal Articles
J Cell Sci (2020) 133 (6): jcs238527.
Published: 26 March 2020
... in glycosylphosphatidylinositol (GPI), localizes to the nuclear envelope (NE). Although this NE localization is essential for Drosophila development, the underlying molecular mechanism remains unknown. To elucidate this mechanism, we identified PIG-B-interacting proteins by performing immunoprecipitation followed by proteomic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (14): jcs229245.
Published: 15 July 2019
..., the nuclear envelope possesses unique mechanical properties, which enables it to resist cytoskeletal forces. Here, we review studies that are beginning to provide quantitative insights into nuclear membrane mechanics. We discuss how the mechanical properties of the fused nuclear membranes mediate...
Journal Articles
J Cell Sci (2019) 132 (10): jcs225524.
Published: 15 May 2019
...Menno Spits; Lennert J. Janssen; Lenard M. Voortman; Raymond Kooij; Anna C. M. Neefjes; Huib Ovaa; Jacques Neefjes ABSTRACT Upon nuclear envelope (NE) fragmentation in the prometaphase, the nuclear and cytosolic proteomes mix and must be redefined to reinstate homeostasis. Here, by using...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (10): jcs229021.
Published: 15 May 2019
... causes lethal defects associated with loss of the nuclear barrier function; the very-long-chain fatty acid elongase Elo2 rescues such lethal defects. Elo2 Fatty acid elongation Fission yeast Lem2 Nuclear envelope Fatty acids are components of lipids, which constitute the intracellular...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (3): jcs221390.
Published: 11 February 2019
...Hardeep K. Gumber; Joseph F. McKenna; Amado L. Estrada; Andrea F. Tolmie; Katja Graumann; Hank W. Bass ABSTRACT The linker of nucleoskeleton to cytoskeleton (LINC) complex is an essential multi-protein structure spanning the nuclear envelope. It connects the cytoplasm to the nucleoplasm, functions...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (20): jcs218024.
Published: 26 October 2018
..., is synthesized by the PIG enzymes. Most PIGs are localized to the endoplasmic reticulum (ER), but Drosophila PIG-B (DmPIG-B) is localized to the nuclear envelope (NE). To determine whether the NE localization of DmPIG-B is functionally important, we defined the determinants of localization and generated an ER...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (18): jcs217513.
Published: 20 September 2018
.... Nuclear morphology Nuclear envelope Lamin Actin Xenopus tropicalis Epidermis Nuclear shape is highly conserved across cell types and species, with most healthy cells having round or ellipsoid nuclei. A few healthy cell types exhibit non-ellipsoid morphologies, including neutrophils, which...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (14): jcs203653.
Published: 20 July 2018
... , M. , Takagi , T. , Osumi , M. , Kimura , A. and Niki , H. ( 2011 ). Breakage of the nuclear envelope by an extending mitotic nucleus occurs during anaphase in Schizosaccharomyces japonicus . Genes Cells   16 , 911 - 926 . 10.1111/j.1365-2443.2011.01540.x Arai , K...
Journal Articles
J Cell Sci (2017) 130 (10): 1822–1834.
Published: 15 May 2017
... sequences that direct nucleoporin nup153 to the inner surface of the nuclear envelope . Chromosoma   107 , 228 - 236 . 10.1007/s004120050301 Fornerod , M. , van Deursen , J. , van Baal , S. , Reynolds , A. , Davis , D. , Murti , K. G. , Fransen , J. and Grosveld , G...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (2): 444–452.
Published: 15 January 2017
...Marta G. Lete; Richard D. Byrne; Alicia Alonso; Dominic Poccia; Banafshé Larijani ABSTRACT Regulation of nuclear envelope dynamics is an important example of the universal phenomena of membrane fusion. The signalling molecules involved in nuclear membrane fusion might also be conserved during...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (24): 4607–4621.
Published: 15 December 2016
.... SIRT2 has also been implicated in the pathology of cancer, neurodegenerative diseases and progeria. Here, we show that SIRT2 depletion or overexpression causes nuclear envelope reassembly defects. We link this phenotype to the recently identified regulator of nuclear envelope reassembly ANKLE2. ANKLE2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (24): 4439–4447.
Published: 15 December 2016
...Marion Weberruss; Wolfram Antonin ABSTRACT The nucleus is enclosed by the nuclear envelope, a double membrane which creates a selective barrier between the cytoplasm and the nuclear interior. Its barrier and transport characteristics are determined by nuclear pore complexes (NPCs) that are embedded...
Journal Articles
J Cell Sci (2016) 129 (22): 4200–4212.
Published: 15 November 2016
...Yasuhiro Mimura; Masatoshi Takagi; Michaela Clever; Naoko Imamoto ABSTRACT Lamin B receptor (LBR), an inner nuclear membrane (INM) protein, contributes to the functional integrity of the nucleus by tethering heterochromatin to the nuclear envelope. We have previously reported that the depletion...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (20): 3770–3780.
Published: 15 October 2016
...Marina Pantazopoulou; Mirta Boban; Roland Foisner; Per O. Ljungdahl ABSTRACT The nuclear envelope is a barrier comprising outer and inner membranes that separate the cytoplasm from the nucleoplasm. The two membranes have different physical characteristics and protein compositions. The processes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (17): 3219–3229.
Published: 01 September 2016
...Zeinab Jahed; Mohammad Soheilypour; Mohaddeseh Peyro; Mohammad R. K. Mofrad ABSTRACT The genetic information of eukaryotic cells is enclosed within a double-layered nuclear envelope, which comprises an inner and outer nuclear membrane. Several transmembrane proteins locate to the nuclear envelope...
Journal Articles
J Cell Sci (2016) 129 (10): 1951–1961.
Published: 15 May 2016
... an essential component of the nuclear lamina, is responsible for autosomal recessive arthrogryposis . Hum. Mol. Genet.   18 , 3462 - 3469 . 10.1093/hmg/ddp290 Baffet , A. D. , Hu , D. J. and Vallee , R. B. ( 2015 ). Cdk1 activates pre-mitotic nuclear envelope dynein recruitment...
Journal Articles
J Cell Sci (2016) 129 (10): 1975–1980.
Published: 15 May 2016
... 3 2016 © 2016. Published by The Company of Biologists Ltd 2016 Highlighted article: We describe a mutation in the human lamin A/C gene that destroys the ZMPSTE24 cleavage site and causes a progeroid disorder. Lamin Nuclear envelope Progeria Mandibuloacral dysplasia ZMPSTE24...
Includes: Supplementary data