... and maintenance. Although these nuclear bodies were discovered decades ago, only recently has in-depth genomic analysis begun to unravel their essential functions in modulation of gene activity. Major advancements in genomic mapping techniques combined with microscopy approaches have enabled insights...

... http://www.biologists.com/user-licence-1-1/ Summary:   Drosophila Prp40 is essential for viability and development, localizes to the histone locus body, and plays a novel role in regulation of histone gene transcription. Nuclear bodies Histone locus body Histone mRNA Drosophila...

... of nuclear speckles over several micrometers after transcriptional inhibition, other stresses and during G2. Interchromatin granule clusters Nuclear bodies Nuclear speckles National Institutes of Health 10.13039/100000002 R01 GM058460 GM112659 National Science Foundation...

...Yana R. Musinova; Olga M. Lisitsyna; Dmitry V. Sorokin; Eugene A. Arifulin; Tatiana A. Smirnova; Roman A. Zinovkin; Daria M. Potashnikova; Yegor S. Vassetzky; Eugene V. Sheval ABSTRACT Nuclear bodies are membraneless organelles that play important roles in genome functioning. A specific type...

...-localize with microinjected DQ-OVA ( Fig. 6C ). By contrast, significant co-localization was observed between splicing factor SC35, a signature protein of splicing speckles, and DQ-OVA in bright nucleoplasmic foci ( Fig. 6D , yellow). A subpopulation of PML nuclear bodies, visualized by antibodies to PML...

... the nucleus, which we termed STAT3 nuclear bodies. To examine the dynamics of STAT3 nuclear body formation, a fusion protein of STAT3 and yellow fluorescent protein (YFP) was constructed. Studies in living cells have shown that the appearance of STAT3 nuclear bodies is transient, correlating...

... for its self-oligomerization activity, truncation or mutation of predicted sites of phosphorylation in the conserved C-terminal region leads to a striking alteration in the number of nuclear bodies. Similarly, coilin constructs from various species display differential propensities to form nuclear foci...