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Keywords: NuMA
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Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2020) 133 (24): jcs240267.
Published: 29 December 2020
... versions of Cep215 with different domain deletions, we conclude that Cep215 plays a role in maintaining the structural integrity of the spindle pole by providing a platform for the molecules involved in centrosome maturation. Fig. 8. Mitotic phenotypes and NuMA dispersion in RNAi-treated CHO   cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (14): jcs243857.
Published: 31 July 2020
...Riya Keshri; Ashwathi Rajeevan; Sachin Kotak ABSTRACT Proper orientation of the mitotic spindle is critical for accurate development and morphogenesis. In human cells, spindle orientation is regulated by the evolutionarily conserved protein NuMA, which interacts with dynein and enriches...
Includes: Supplementary data
Journal Articles
In collection:
Polarity
J Cell Sci (2018) 131 (10): jcs214544.
Published: 21 May 2018
...), NuMA (also known as NUMA1) and dynein–dynactin, plays a key role in establishing proper spindle orientation. It has also been shown that the actin-binding protein MISP and the ERM family, which are activated by lymphocyte-oriented kinase (LOK, also known as STK10) and Ste20-like kinase (SLK) (hereafter...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (15): 3015–3025.
Published: 1 August 2016
... localization at the cell cortex. Moreover, we show that Aurora A and the PP6 phosphatase subunit PPP6C are also necessary for spindle positioning in human cells. There, Aurora A is needed for the cortical localization of NuMA and dynein during mitosis. Overall, our work demonstrates that Aurora A kinases...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (9): 1596–1606.
Published: 1 May 2007
... splicing factor speckles, and distinct nuclear mitotic apparatus protein (NuMA) foci. Upon alteration of nuclear organization using an antibody against NuMA, differentiated non-neoplastic cells undergo apoptosis, whereas partially differentiated malignant cells enter the cell cycle. Non-neoplastic cells...
Journal Articles
J Cell Sci (2004) 117 (26): 6391–6400.
Published: 15 December 2004
...Olga Kisurina-Evgenieva; Gary Mack; Quansheng Du; Ian Macara; Alexey Khodjakov; Duane A. Compton The large coiled-coil protein NuMA plays an essential role in organizing microtubule minus ends at spindle poles in vertebrate cells. Here, we use both in vivo and in vitro methods to examine NuMA...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2003) 116 (3): 571–583.
Published: 1 February 2003
...Pekka Taimen; Markku Kallajoki NuMA is a nuclear matrix protein that has an essential function in the organization of the mitotic spindle. Here we have studied the fate of NuMA in Fas-treated apoptotic Jurkat T and HeLa cells. We show that in both cell lines NuMA is an early target protein...
Journal Articles
J Cell Sci (1999) 112 (14): 2453–2461.
Published: 15 July 1999
... nucleotide exchange factor RCC1, stabilises large microtubule asters nucleated at the sperm centrosome, prevents the redistribution of NuMA from the aster to the nucleus and blocks chromatin decondensation. In contrast, Ran GDP does not stabilise microtubules or inhibit nuclear assembly. RanT24N and RanBP1...
Journal Articles
J Cell Sci (1999) 112 (4): 455–466.
Published: 15 February 1999
... redistribution of the protein during mitosis, B23 also becomes associated with mitotic spindle poles starting from early prometaphase onwards. Colocalization of B23 with the protein NuMA (Nuclear Mitotic Apparatus protein) was studied in mitotic cells and taxol-arrested cells. During the onset of mitosis, we...
Journal Articles
J Cell Sci (1998) 111 (16): 2305–2313.
Published: 15 August 1998
... of apoptosis to double that of spontaneous apoptosis in controls within 6 hours. Immunolabelling for Nuclear Mitotic Apparatus Protein (NuMA) suggested that splenocytes were responding heterogeneously to the heat treatment. Whereas all nuclei in controls and about half of nuclei in heat-treated samples showed...
Journal Articles
J Cell Sci (1998) 111 (1): 71–79.
Published: 1 January 1998
...Andreas Merdes; Don W. Cleveland ABSTRACT NuMA is an essential protein for the formation of spindle poles in mitosis. During interphase, NuMA is transported into the nucleus where it resides until prometaphase of the next mitotic cycle. We tested for a potential function of NuMA in interphase...
Journal Articles
J Cell Sci (1997) 110 (11): 1287–1297.
Published: 1 June 1997
...Alejandro Saredi; Louisa Howard; Duane A. Compton ABSTRACT NuMA is a 236 kDa nuclear protein that is required for the organization of the mitotic spindle. To determine how NuMA redistributes in the cell during mitosis, we have examined the behavior of NuMA in a mammalian mitotic extract under...
Journal Articles
J Cell Sci (1996) 109 (3): 619–630.
Published: 1 March 1996
...Alejandro Saredi; Louisa Howard; Duane A. Compton ABSTRACT NuMA is a 236 kDa protein that participates in the organization of the mitotic spindle despite its strict localization in the nucleus during interphase. To test how cells progress through mitosis when NuMA is localized in the cytoplasm...
Journal Articles
Journal Articles
J Cell Sci (1996) 109 (1): 45–56.
Published: 1 January 1996
... initiate the cascade of degradative events in apoptosis. * Author for correspondence (e-mail: [email protected] ) 10 08 1995 18 10 1995 © 1996 by Company of Biologists 1996 NuMA Lamin B Phosphorylation Site-specific proteolysis MacDonald et al. (1980...
Journal Articles
J Cell Sci (1995) 108 (11): 3389–3396.
Published: 1 November 1995
...C. A. Sparks; E. G. Fey; C. A. Vidair; S. J. Doxsey ABSTRACT NuMA, the nuclear mitotic apparatus protein, is a component of the nuclear matrix at interphase that redis-tributes to the spindle poles at mitosis. While the function of NuMA is not known, it has been implicated in spindle organization...
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